X. Liu

This study maps cisplatin-damaged gene loci and identifies key pathways and targets, revealing SPAG9 as a potential therapeutic target for testicular cancer.

This study develops an intranasal vaccine that induces systemic and mucosal immunity against SARS-CoV-2 in mice, with single-cell RNA-sequencing confirming T and B cell responses in nasal-associated lymphoid tissues.

This study shows that deleting Nupr1 in HSCs activates quiescence, enhancing engraftment without affecting stemness or differentiation.

This study identifies fibroblast subpopulations in mouse and human lungs using scRNA-seq, revealing conserved transcriptomic signatures and their roles in fibrosis.

This study validates the use of GANs for virtual trichrome staining of NASH liver biopsies, showing high correlation with real stains and clinical outcomes.

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

This paper performs population pharmacokinetics analysis of camrelizumab and finds no significant advantage of flat-dose or weight-based dosing regimens.

The paper designs small molecules that target the structural differences in miR-200 precursor family members to selectively reverse a type 2 diabetes phenotype.

This study shows berberine reverses multidrug resistance in Candida albicans by hijacking the Mdr1p efflux pump for drug import, leading to mitochondrial dysfunction and selective cell death.

The paper shows BTK modulates NLRP3 inflammasome activity through phosphorylation of tyrosine residues, affecting localization, oligomerization, and IL-1β release.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

The paper shows that immune cell dynamics in peripheral blood reflect tumor-immune interactions during immunotherapy, with responder patients showing increased cytotoxic differentiation and interferon signaling.

The paper uses Ligand Class Analysis to identify target genes and coregulator interactions of glucocorticoid receptor ligands, revealing mechanisms linking ligand structure to physiological outcomes.

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

This study tracks the dynamic localization of Japanese encephalitis virus (JEV) in mouse brain nuclei over time, revealing its progression from thalamus and medulla oblongata to widespread distribution in the central nervous system.

This study shows that depletion of FOXA1/2 in human liver cells reprograms differentiation state and metabolism, promoting de-differentiation and pluripotency.

This paper develops a deep learning model to detect cancer regions and estimate PD-L1 tumor proportion scores in lung adenocarcinoma IHC slides, showing strong agreement with pathologists' interpretations.

This study identifies histone lysine crotonylation as an active promoter mark that regulates gene expression and neuronal differentiation in neural stem/progenitor cells.

The paper demonstrates content-based image similarity search using a database of 1.6 million images encoded in synthetic DNA, achieving retrieval rates greater than chance.

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

This study uses single-cell RNA-seq to analyze keloid tissue and identifies lineage-specific regulatory changes in fibroblasts and vascular endothelial cells, highlighting key pathways and potential therapeutic targets.

This study rapidly identifies a potent human monoclonal antibody against SARS-CoV-2 that neutralizes the virus in animal models and shows promise for therapeutic use.

This study demonstrates that ADXS-NEO, a personalized Listeria monocytogenes vaccine, effectively targets tumor-specific mutations and controls tumor growth in mice by inducing neoantigen-specific T cell responses.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This paper identifies N-glycosylation as essential for Phytophthora sojae growth and pathogenicity, revealing two distinct N-glycosylation motifs and their functional roles in key life stages.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study develops a vaccine candidate against SARS-CoV-2 using virus-like particles displaying the receptor binding domain, which induces neutralizing antibodies in mice.

This study shows that skin scarification delivery of MVA vectors generates robust T cell immunity against respiratory viral challenges, outperforming other routes and suggesting its potential for vaccines like COVID-19.

The paper identifies low-molecular-weight drugs that inhibit SARS-CoV-2 main protease using a fragment-based approach, finding niacin and hit 1 bind to the catalytic pocket and leading to the discovery of four drug candidates.

The paper maps a comprehensive cytokine gene regulatory network using eY1H assays, identifying 1,380 TF-cytokine gene interactions and novel regulatory axes in immune diseases.