X. Liu

This study shows that TAM proliferation in PDAC is driven by CSF1 from fibroblasts, leading to immunosuppression and tumor progression, but also increasing sensitivity to CD40 agonist therapy.

This study identifies ETV2 as a regulator of cell death in Tsc2-deficient cells through PARPBP and ER stress, suggesting a potential therapeutic target for LAM.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

This study shows mRNA vaccines induce rapid antibody responses in mice by day 5, outperforming DNA, protein, and adenovirus vaccines for SARS-CoV-2 and HIV-1 antigens.

This paper assesses Virtual Trichrome technologies using Bridge Category Models to account for bridge ratings in Fibrosis staging of NASH tissue.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

The paper identifies adaptive mutations in diploid yeast by analyzing fitness effects of evolved mutations and finds that overdominant and partially dominant mutations contribute to short-term adaptation.

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

The paper isolates and characterizes two novel photosystem I supercomplexes from cyanobacteria, revealing the structure of the PSI octamer at near-atomic resolution.

This study uses top-down proteomics to identify 23,319 proteoforms in colorectal cancer cell lines and finds significant proteoform-level differences between metastatic and non-metastatic cells.

This paper develops hierarchical Bayesian models to assess inter- and intra-rater reliability for NASH fibrosis staging, showing improved precision over ad hoc methods.

The paper establishes the near-atomic molecular architecture and evolutionary conservation of the linker-scaffold in the human nuclear pore complex.

The paper reviews marine microbiome studies, analyzes 17.59 Tb of sequencing data, and constructs genome and gene catalogues to explore marine prokaryotic diversity and function.

This study shows that Hoxb5 can convert multipotent blood progenitors into hematopoietic stem cell-like cells with long-term repopulating ability.

The paper identifies SeASF1 and SeH4 as regulators of the PI3K/AKT pathway in filamentous ascomycete, influencing sexual and asexual development through interactions with SeDJ-1 and SePI3K.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study investigates how different IgG isotypes in human milk influence antibody-dependent cellular phagocytosis (ADCP) of HIV by milk leukocytes, finding isotype-specific effects on phagocyte activity.

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

This study shows that Midkine suppresses AMPK activation by disrupting the LKB1-STRAD-Mo25 complex, promoting cancer cell proliferation and correlating with poor clinical outcomes in specific cancers.

The paper presents cryo-EM structures of the yeast clamp loader RFC bound to PCNA, revealing the mechanism of clamp opening and DNA binding without ATP hydrolysis.

This paper shows that PcGCE, a microbial enzyme, acts as a pathogen-associated molecular pattern in aspen, triggering immune responses and growth retardation when expressed in transgenic plants.

This paper develops an in-situ printing system using a human platelet lysate-based bio-adhesive to treat corneal perforations, showing improved adhesion, burst pressure, and faster healing in rabbits compared to cyanoacrylate glue.

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

The paper characterizes Sulfolobus islandicus DNA polymerase 2 (Dpo2), showing it extends mismatches and lesions but lacks 3-5 exonuclease activity, suggesting a role in DNA repair.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

The paper shows that Rrp36 regulates ribosome assembly by preventing a dead-end pathway, allowing Has1 to correct misfolding and ensure proper platform assembly.

This study identifies Lem8, a protease effector from Legionella pneumophila, which inhibits host cell motility by targeting Phldb2 via 14-3-3ζ-dependent activation.

The paper develops genetically encoded tagged versions of PFN1 to study its interactions with actin and microtubules in vitro and in live cells, revealing functional insights into PFN1's role in cellular processes and disease.