X. Wang

The paper uses super-resolution imaging to show that different RNA sequence domains localize to distinct regions within nuclear speckles, driven by RNA-protein interactions.

This study shows that influenza virus infection impairs neutrophil and monocyte function, reducing Aspergillus fumigatus conidia clearance and increasing invasive aspergillosis in mice.

This study improves the phylogenetic understanding of Lepidoptera by increasing taxon sampling and analyzing the impact of sampling and long-branch attraction on tree topology.

This study identifies BCAM as a marker of airway basal stem cells and shows that T2 cytokines drive their expansion via IRS signaling in CRSwNP.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This paper develops a novel mouse model of TNBC by combining MYC amplification and PTEN deletion, showing it recapitulates human TNBC heterogeneity through omic analyses.

This paper introduces a framework for multi-model ensemble modeling to predict malaria vector larval habitats, finding that ensembled models improve prediction accuracy by 20% compared to individual models.

This paper develops a host-guest chemistry strategy using cyclodextrins to stabilize GSNO and control NO release, improving its therapeutic and anti-infective applications.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study shows that PKR inhibition reduces mitochondrial dysfunction and ameliorates HIV-associated nephropathy in transgenic mice using single-nucleus and bulk RNA-seq.

This study identifies two progenitors of sweetpotato using horizontal transferred T-DNA and haplotype-based phylogenetic analysis, revealing its origin from a reciprocal cross and whole genome duplication.

This study shows CD47 stabilizes the extended conformation of Mac-1 integrin, enhancing macrophage functions like adhesion and phagocytosis.

The paper finds that early season soil microbial data best predict wheat grain quality, with LASSO regression models highlighting key microbial parameters.

The paper profiles global mosquito viromes across species, locations, and climates, identifies core-viruses, and links viral diversity to ecological factors and mosquito movement.

The paper identifies synergistic drug combinations for T-ALL using high-throughput screens and develops lipid nanoparticle formulations that maintain drug synergy and improve anti-leukemic activity.

This study investigates how zearalenone promotes colorectal cancer in mice through multi-omics analyses, revealing pathway activation, metabolic changes, and microbiota alterations.

The paper shows that mutations in mitochondrial preproteins cause clogging of the import pathway, leading to disease by impairing mitochondrial function and cell viability.

This study maps and models human colorectal carcinoma interactions with the tumor microenvironment using single-cell transcriptomics and tumoroid cultures, showing how tumoroids suppress inflammation and reprogram macrophages.

This study investigates the interactions between cisplatin and E-cadherin using fluorescence spectroscopy and AFM, revealing strong binding and structural changes.

This study identifies FBXO11 loss as a driver of AML by promoting a stem cell program through mitochondrial dysregulation.

This study identifies GLKs as regulators of carotenoid biosynthesis through GBF-dependent transcriptional activation and phase separation-mediated nuclear condensates.

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.

The study identifies CsFLC1 in tea plants, showing it influences flowering and bud dormancy, and demonstrates its function in Arabidopsis by promoting early flowering and affecting gene expression related to flowering and hormone pathways.

This study shows dexamethasone enhances CAR T cell persistence and function by upregulating IL7R, improving anti-tumor efficacy in vivo.

This study combines thermosensitive liposomes, localized hyperthermia, and immune checkpoint inhibition to enhance systemic anti-tumor effects in a murine model of rhabdomyosarcoma.

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

This study identifies impaired SR Ca2+ signaling and disrupted ion channel activity in Col4a1 mutant mice as contributors to age-related cerebral small vessel disease.

The paper uses single-cell RNA-seq to analyze factors influencing CD4 T cell activation and identifies distinct functional states and differentiation patterns.