X. Yang

This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

The paper identifies distinct extracellular tRNA-derived small RNA (tDR) fragmentation signatures associated with different stress responses and shows their potential as biomarkers in human disease.

This study identifies HNF1B as a key mediator of prostate cancer risk through its interaction with TMPRSS2-ERG fusion, revealing germline-somatic interplay in disease progression.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This study shows FtsN activates septal peptidoglycan synthesis by forming a processive complex with FtsWI on the sPG-track, rather than displacing FtsWI from the Z-track.

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

This study uses FLIM to measure metabolic state in human blastocysts, finding metabolic differences related to time since fertilization and developmental stage, but not morphology.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study identifies TMEM-120/TMEM120A as a conserved protein that promotes fat storage by enhancing triacylglycerol synthesis and lipid droplet expansion in C. elegans and mammalian cells.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

The paper reports the structures of M. tuberculosis cytochrome bcc complexed with two anti-TB drugs, revealing binding sites and interactions that inform inhibitor design.

This study shows that genetic inhibition of SGK1 reduces obesity-related atrial fibrillation in mice by decreasing fibrosis, inflammation, and altering electrophysiology.

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

This study identifies endophilin A1 as a calmodulin effector that drives dendritic spine enlargement via actin polymerization during LTP induction.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

PodoCount quantifies podocytes in kidney tissues with high accuracy, showing strong correlation with disease diagnosis and clinical outcomes in both murine models and human diabetic nephropathy.

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

The paper identifies three plasmid combinations that enhance the spread of ST11/CG258 carbapenemase-producing Klebsiella pneumoniae in China through genomic and epidemiological analysis.

This study shows that INT-767 prevents fibrosis in iPSC-derived renal organoids by modulating the TEAD4/TAZ pathway.

This study maps genetic diversity across Zea species, identifying millions of variants and adaptive genes, and demonstrates their utility in breeding.

This paper develops a method to create semi-synthetic proteoglycans for studying their structure-function relationships in cell biology.

The study compares antibody responses in asymptomatic and symptomatic SARS-CoV-2感染者, finding that symptomatic individuals maintain higher and longer-lasting IgG and neutralizing capacities.

This study identifies that biofilm-forming E. coli from slaughter plant equipment are more prevalent and resilient than those from cattle, suggesting that current antimicrobial interventions may inadvertently select for robust biofilm-formers.

The paper identifies a novel SARS-CoV-2-related bat virus, PrC31, with complex recombination events and partial genetic similarity to SARS-CoV-2.

This study identifies AcMNPV orf13 as essential for efficient nuclear egress of nucleocapsids during virion budding but not for occlusion body formation.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

This paper identifies host proteins proximal to 17 SARS-CoV-2 viral proteins, revealing mechanisms of antiviral signaling disruption and host translation inhibition.

The paper uses single-cell RNA analysis to compare immune cell profiles in young and old mice, finding higher proportions of effector cells in old mice that may enhance tumor defense.

This study shows that STK3, typically a tumor suppressor, promotes prostate cancer growth and identifies STK3 inhibitors with therapeutic potential.