X. Yang

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

The paper shows that Bt-cotton adoption in China increased the prevalence of a symbiotic virus in the cotton bollworm, enhancing its resistance to Bt-cotton.

This study evaluates the neutralization of SARS-CoV-2 501Y.V2 variant by antisera from two Chinese vaccines, showing preserved neutralizing titres against the variant.

This study reports cryo-EM structures of CALHM1 channels and proposes a mechanism for ATP permeation through dynamic N-helix movement.

This paper uses spatial single-cell omics to analyze PDAC tumors and microenvironment, identifying key populations and interactions that may inform treatment strategies.

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

This paper develops an ultrasensitive biosensor to quantify SARS-CoV-2 RBD and ACE2 interactions in cells and in vitro, enabling rapid evaluation of viral mutants and drug candidates.

This study identifies age-related downregulation of angiogenic, Notch, and Wnt pathways in peri-implant tissue, linked to immune activation and impaired osseointegration in aged mice.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

This study presents the first de novo genome of Jasminum sambac and identifies gene clusters and pathways involved in flower fragrance biosynthesis.

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

This study develops and tests a recombinant RBD-Fc vaccine against SARS-CoV-2, showing protection in non-human primates and mice.

This paper develops a coarse-grained NADH redox model to infer subcellular mitochondrial metabolic fluxes from fluorescence lifetime imaging in mouse oocytes and human cells.

This study identifies a conserved ubiquitin- and ESCRT-dependent pathway for degrading lysosomal membrane proteins in human and yeast cells.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

The paper shows that mammary ductal epithelial cells regulate cold-induced adipocyte thermogenesis via secreted factors called mammokines in female mice.

This study shows that SARS-CoV-2 ORF3a induces incomplete autophagy by interacting with UVRAG, impairing autophagosome maturation and enhancing viral replication.

A mouse-adapted SARS-CoV-2 strain with RBD mutations caused 100% mortality in aged male BALB/c mice and showed altered receptor binding affinity.

This study shows SARS-CoV-2 infection causes temporary olfactory dysfunction in mice by targeting olfactory epithelium cells and disrupting their structure and function.

The paper develops a mathematical model to explain cross-species differences in myofibroblast effects on cardiomyocytes, identifying transient K+ currents as a key factor.

The paper reanalyzes a single-cell RNA-Seq dataset to identify cellular and molecular differences in severe versus mild COVID-19, suggesting potential biomarkers for disease severity.

This study shows that evolutionary arms race between bat SARSr-CoV spike proteins and ACE2 drives genetic diversity, with SARSr-CoV spike proteins showing higher binding affinity to human ACE2 than bat ACE2.

This study identifies two distinct processive motions of FtsW in E. coli, driven by FtsZ treadmilling or septal peptidoglycan synthesis, revealing a two-track model for sPG synthesis regulation.

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

This study shows telmisartan enhances insulin secretion via ion channels, independent of AT1 receptor and PPARγ, in rat islets and diabetic mice.

This study analyzes cerebrospinal fluid from healthy pregnant women and finds no evidence of a detectable microbial community after accounting for contamination.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

This study shows SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, causing electrical and mechanical dysfunction in cardiac cells.