X. Zhu

This study investigates the biogenesis of propanediol-utilization metabolosomes in bacteria, revealing both 'Shell first' and 'Cargo first' assembly pathways.

The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

This paper introduces a novel COVID-19 vaccine based on a RBD-HR1/HR2 hexamer structure that induces high neutralizing antibody titers and alternative antibodies targeting the HR1 region in mice.

This study develops two PROTACs targeting NAMPT, showing they degrade the protein more effectively than FK866 in tumor cells, highlighting PROTACs as a better strategy for dual-function proteins.

This study uses cryo-EM to analyze disease mutations and inhibitor binding in p97, revealing how these affect allosteric activation and provide insights into their mechanistic link to dysfunction.

This study shows that hematopoietic SLC37A2 deficiency accelerates atherosclerosis in LDL receptor-deficient mice by impairing anti-inflammatory responses and IL-10 production.

This study investigates how calreticulin exon-9 INDEL mutations affect calcium signaling and contribute to essential thrombocythemia through structural changes and reduced calcium binding.

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

This study shows that rhesus macaques can be immunized to produce broadly neutralizing antibodies against multiple SARS-related viruses, highlighting differences in B cell repertoires between humans and macaques.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This paper describes engineering a SARS-CoV-1 neutralizing antibody to effectively neutralize SARS-CoV-2 through directed evolution and affinity maturation.

This study models how ploidy and pathogen life cycle affect resistance durability in plant-pathogen systems, finding that diploids show greater stochasticity and delayed resistance breakdown.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.

This study develops glycan-modified SARS-CoV-2 nanoparticle vaccines that induce potent neutralizing antibodies and single-dose protection against SARS-CoV-2 in multiple animal models.

This study identifies mutations in wzc and wcaJ genes in hypervirulent Klebsiella pneumoniae that confer phage resistance but reduce virulence.

This study identifies Vibrio cholerae in diseased bullfrogs and suggests it can transmit to humans via bullfrog food and aquaculture water, posing a health risk.

This study identifies a broadly neutralizing antibody that targets a conserved site on beta-coronavirus spike proteins and provides protection against SARS-CoV-2 infection.

This study shows mTORC2 promotes Tfh differentiation and disrupts Treg homeostasis, contributing to systemic autoimmunity, and suggests mTORC2 as a potential therapeutic target.

This study evaluates how N-linked glycans on Lassa virus GPC affect immune response, finding that glycan deletion enhances effector T cell proportions and antibody titers, suggesting potential for vaccine design.

This study shows dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction by targeting mitochondrial PDC/PDK energy homeostasis in a mouse model.

The paper examines how mutations at E484 and K417 in SARS-CoV-2 variants affect neutralizing antibodies, showing reduced efficacy against certain antibody families but not others.

This study shows that combining cross-neutralizing antibodies CV38-142 and COVA1-16 enhances neutralization of SARS-CoV-2 and SARS-CoV pseudoviruses.

This study compares the robustness of microbiota association inference using stool, swab, and mucosal tissue samples in a larger cohort, finding that mucosal samples yield less consistent results than stool or swab.

The paper identifies two public IGHV3-53/3-66 clonotypes with distinct CDR H3 motifs and shows Y58F mutation enhances binding affinity to SARS-CoV-2 RBD.

The paper presents cryo-EM structures of the N501Y SARS-CoV-2 spike protein complex with ACE2 and neutralizing antibodies, showing increased ACE2 binding affinity and retained epitopes.