Y. Cao

This study identifies the role of renal macrophages in clearing intratubular particles and preventing kidney stone formation through phagocytosis and transmigration.

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

This paper develops a predator-prey model to simulate tumor-immune interactions and immunotherapy response using preclinical and clinical data.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This study constructs multiscale models of SARS-CoV-2 using coarse-grained molecular dynamics simulations and experimental data, revealing dynamic behavior of membrane proteins and lipid interactions.

This study quantifies how Omicron variant's RBD mutations enhance binding affinity to ACE2 compared to the original SARS-CoV-2 strain.

This study shows that sole NH4+ supply reduces photosynthesis in Lonicera Japonica by decreasing mesophyll conductance, driven by thicker cell walls and reduced chloroplast surface area.

The paper shows that neural stemness unifies tumorigenicity and pluripotent differentiation potential by demonstrating SETDB1's role in maintaining these properties through epigenetic and transcriptional mechanisms.

This study develops an enzyme-based method to extract plant extracellular vesicles, showing higher yield and therapeutic potential compared to traditional methods.

This study shows that myofibroblast senescence in aged infarcted rabbit hearts promotes arrhythmogenic remodeling by coupling with myocytes and prolonging action potential duration.

This study tracks immune cell changes in early systemic lupus erythematosus using mass cytometry and identifies longitudinal shifts in Tfh cells and CXCL10.

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

This study uses molecular dynamics and experiments to analyze how mutations in SARS-CoV-2 variants affect their binding to ACE2, identifying which variants are more contagious.

This study shows NSUN2-mediated m5C methylation of IRF3 mRNA reduces type I interferon responses by promoting IRF3 mRNA degradation, and NSUN2 levels decrease during viral infection to enhance antiviral immunity.

This paper develops a protein hydrogel that mimics articular cartilage by combining physical entanglements and force-induced unfolding, achieving mechanical properties comparable to natural cartilage.

This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.

This study identifies the roles of histone acetyltransferases and deacetylases in the growth, virulence, stress resistance, and DNA repair of Alternaria alternata through gene deletion mutants.

This study uses molecular dynamics simulations to analyze SARS-CoV-2 spike protein interactions with antibodies, revealing structural dynamics and mutation impacts on neutralization.

The paper presents autopsies of Covid-19 patients showing pulmonary stromal expansion and intra-alveolar coagulation as primary causes of death, with virus replication in pneumocytes and macrophages.

This study profiles co-transcriptomes of Arabidopsis and its associated bacteria to understand molecular interactions and bacterial adaptation mechanisms.

The paper develops a PD-L1 and TLR7 dual-targeting nanobody-drug conjugate that synergistically activates innate and adaptive immune responses, showing potent antitumor effects in both 'hot' and 'cold' tumors.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

This paper develops a method using gold nanoclusters to deliver siRNA into plant cells, achieving efficient gene knockdown with minimal toxicity.

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

The paper identifies two non-canonical GPCRs, D6R and C5aR2, that exclusively couple to β-arrestins and exhibit distinct GRK preferences and downstream signaling.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.