Y. Chen

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

The paper uses single-cell sequencing to analyze hypertrophic scars, identifying serine proteases as key regulators of myofibroblast differentiation and suggesting their inhibition for treating skin fibrosis.

This study generates and tests human embryonic stem cell-derived immunity-and-matrix-regulatory cells (IMRCs) for treating lung injury and fibrosis in mice, showing efficacy and safety.

This study identifies inhibitors of SARS-CoV-2 main protease that show potent antiviral activity in cell culture.

This study shows that robust biofilm formation in environmental Bacillus subtilis strains reduces competent cell rates through cross-pathway regulation between biofilm and competence systems.

The paper isolates and characterizes Klebsiella species from preterm infants, revealing diverse species and antimicrobial resistance traits associated with health and disease.

This study examines how environmental factors and landscape heterogeneity influence genetic structure in wild rice Zizania latifolia across a latitudinal gradient in China.

This study identifies an immune class in prostate cancer associated with better recurrence-free survival and response to anti-PD-1/PD-L1 immunotherapy.

This study reconstructs the three-dimensional vasculature of Anaxagorea carpels, finding a radiosymmetrical pattern consistent with the Unifying Theory of carpel origin.

This study uses structure-guided mutagenesis to identify PLP2 DUB activity as an interferon antagonist in murine coronavirus pathogenesis.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This study shows that cell-ECM interactions in the fluidic phase determine epithelial structure topology and polarity through ECM topology and biomechanical cues.

The paper introduces a method to label subcellular structures in living specimens using live-cell incompatible dyes under specific conditions, revealing their potential for imaging.

This study uses chemoinformatics to engineer polyketide synthases for producing saturated β-carbon compounds, finding a correlation between chemical similarity and product titers.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

This study isolates multiple SARS-CoV-2-neutralizing antibodies through site-directed screening, showing potent protection against virus infection.

This study shows prohibitin protects human pulmonary microvascular endothelial cells from cigarette smoke extract-induced apoptosis by preserving mitochondrial function and reducing oxidative stress.

The paper identifies a novel prophage-encoded defense mechanism in Cluster N mycobacteriophages, showing that genes 30 and 31 form a two-component system that partially protects against heterotypic phage infection.

This study introduces a novel pancreatic cancer dormancy model, identifies a dormancy gene signature, and reveals mechanisms including chromatin remodeling and CCL5 as a novel marker.

This study identifies IRE1 kinase as a mediator of inflammation-induced adipocyte lipolysis, distinct from adrenergic or hormonal regulation.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

The paper investigates how lectin-like intestinal defensin HD5 inhibits 2019-nCoV Spike protein binding to ACE2, showing a high-affinity interaction and protective effect in vitro.

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

This paper proposes a two-stage deep learning method for ECG denoising using U-net and DR-net models, showing improved performance over single-stage methods.

This paper develops a sensitive and reusable method for detecting Exo III activity using DNB nanoarrays and cPAS sequencing technology, showing a linear response in low concentration ranges.

The paper identifies recombination and purifying selection in coronaviruses from different hosts as key factors in SARS-CoV-2 emergence.

Sulfopin, a selective Pin1 inhibitor, reduces tumor initiation and growth in neuroblastoma models by targeting c-Myc pathways.

This study characterizes an obese ZSF1 rat model of cardiometabolic syndrome and shows that GDF15 treatment reduces metabolic markers and improves cardiac function.

The paper identifies two genes in Populus deltoides that antagonistically regulate sex determination by repressing female structures and promoting male structures through epigenetic and RNA-based mechanisms.

This study isolates a halotolerant Pseudomonas aeruginosa strain capable of degrading waste cooking oil and producing rhamnolipids, achieving high degradation rates and surfactant yields.