Y. Jin

The paper identifies TAZ as a molecular switch driving phenotypic transition and metastasis in SCLC by analyzing mouse models and human data.

The paper identifies RYR1 as a key channel regulating sweet and umami perception in rats through Ca2+ dynamics and proposes a metabolic clock model.

This study identifies NSD1/2 as key writers and LEDGF/HDGF2 as readers of H3K36me2 in H3K27M-DIPG, showing their role in tumor proliferation and suggesting therapeutic targeting.

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

The paper maps root-microbe interactions in Arabidopsis thaliana by identifying host genetic variants and microbial hubs that influence microbial network structures and functions.

This study investigates the role of Rickettsia-infected endothelial cell-derived exosomes in causing barrier dysfunction in brain microvascular endothelial cells, identifying miR-23a and miR-30b as key regulators.

The study examines the link between Toxoplasma gondii infection and physical education scores in college students, finding higher scores in infected students in specific sports.

This study shows that ER chaperones BiP and Grp94 regulate proIGF2 folding and oligomerization, with BiP suppressing and Grp94 enhancing oligomerization under different ATP/ADP conditions.

This study identifies phosphorylated residues in RBM20, showing their role in splicing control and protein shuttling, and links their mutation to cardiac dysfunction.

This study shows EPAC1 regulates vWF secretion from endothelial cells during inflammation via the PI3K/eNOS pathway, with implications for thrombosis control.

The paper determines the structure of SARS-CoV-2 Mpro and shows how GC376 inhibits its catalytic site, supporting its use as an antiviral drug.

This study identifies chemicals highly enriched for spontaneous abortion (SA) genes across human, mouse, and rat species, highlighting potential environmental risks to pregnancy outcomes.

This study shows cells can sense long-range biomechanical forces through the matrix to initiate distant mechanical communication, enabling coordinated self-assembly.

This study reports the financial and economic costs of a nationwide schistosomiasis and intestinal helminthiases survey in Sudan, identifying personnel and transportation as key cost drivers.

The paper models how changes in heart rate affect ocular pulse and biomechanical properties of the optic nerve head, finding decreased pulse amplitude and increased stiffness with higher heart rates.

The paper identifies dysbiosis in RA tonsillar microbiota and shows that Streptococcus salivarius and its antibacterial peptides modulate autoimmunity by suppressing T cells and autoantibodies.

This study identifies BCAT1-mediated metabolic reprogramming as a mechanism of EGFR TKI resistance in lung cancer and shows that combining TKI with ROS-inducing agents can overcome resistance.

This study identifies subtype-specific influenza A virus-host protein interactions that correlate with different pathogenic outcomes.

This study shows PID1 increases lipolysis by inhibiting insulin's antilipolytic effect through the AKT/PKA/HSL pathway in adipose tissue.

This study shows ionomycin treatment rescues osteoporosis in HPP by restoring Ca2+ influx via ALPL-mediated L-type Ca2+ channel trafficking in BMSCs.

This paper introduces a deep learning method that achieves super-resolution in fluorescence microscopy without requiring numerical models or parameter tuning, successfully resolving images with low numerical aperture lenses and diffraction-limited confocal microscopy.

This study investigates how macromolecular crowding affects single-round transcription by E. coli RNA polymerase, finding unexpected enhancements in kinetics with large crowders.

This study shows that PRC2 activity is controlled by allosteric activation, independent of its chromatin recruitment, and identifies vulnerabilities in PRC2-addicted cancers.

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.

The paper investigates how diet shifts between freshwater and seawater affect lipid metabolism regulation in Atlantic salmon, identifying gene expression changes and evolutionary impacts of whole-genome duplication.