Y. Xie

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This study shows that Mfge8 inhibits human gastric antrum smooth muscle contractions by reducing MYPT1 phosphorylation and LC20 phosphorylation through its interaction with 8β1 integrin.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study shows that the S1/S2 boundary of the SARS-CoV-2 spike protein affects cell entry and transmission by altering the pathway used for viral entry.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.

This study examines the relationship between neuroendocrine and immune gene expression in SCLC, finding that variant SCLC tumors regain immune gene expression and exhibit higher tumor-immune interactions.

The paper investigates how multiple actin regulators coordinate to form complex 3D actin structures in vivo, identifying distinct roles and cooperative interactions among seven ANRPs.

The paper identifies a proto-sex locus in large yellow croaker, showing reduced recombination and dmrt1 expression in testis development and shared functional links between genetic sex determination and environmental sex reversal.

This study shows glucocorticoids reduce macrophage phagocytosis, increasing bacterial burden in a zebrafish tuberculosis model, which may explain increased susceptibility to tuberculosis in humans.

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

This study shows that immunization with SARS-CoV-2 RBD induces antibodies that neutralize both SARS-CoV-2 and SARS-CoV without causing antibody-dependent enhancement.

This study identifies three Npl4 conformational states in the human p97 complex using cryo-EM and shows how a disulfiram derivative inhibits p97 by disrupting Npl4 zinc finger interactions.

The paper shows that pericytes, not endothelial cells, express ACE2 in microvessels, suggesting they may be infected in COVID-19 and contribute to microvascular inflammation and hypercoagulopathy.

This study identifies PDE6D as a potential target of sorafenib using PROTAC technology and proteomic analysis.

This study shows that protoporphyrin IX and verteporfin inhibit SARS-CoV-2 infection in vitro and in a human ACE2-expressing mouse model by blocking ACE2-S protein interaction.

This study identifies ACE2 orthologs from diverse species that can support SARS-CoV-2 entry, suggesting a broad host range for the virus.

The paper identifies an immunosuppression signature (IMS) and shows that its ratio to an IFN-γ signature better predicts anti-PD-1 therapy response in melanoma than existing biomarkers.

This study uses human liver organoids to show SARS-CoV-2 infects cholangiocytes, disrupts bile transport, and causes liver damage, suggesting targeting viral effects on the liver could improve COVID-19 treatment.

This study investigates the transcriptomic response of Caenorhabditis elegans to acidic stress environments, identifying two major pathways involved in cuticle synthesis and xenobiotic metabolism.

This study uses OCT to monitor long-term tissue response around brain implants, finding that Parylene coatings do not reduce glial encapsulation.

This study identifies Schisandrin B as a potential treatment for male infertility by improving sperm count, mobility, and reproductive ability in a mouse model.

The paper reports the cryo-EM structure of the Tenm2-Lphn3 complex and shows how alternative splicing regulates synapse specificity by affecting access to the Lphn-binding site.

This study shows that sgRNA expression level is a major determinant of CRISPRi knockdown efficiency in K562 cells, more impactful than KRAB-dCas9 expression level.

This paper investigates carbon metabolism, transcriptome, and RNA editome changes during developmental path differentiation in Coprinopsis cinerea, revealing key metabolic pathways and evolutionary transcriptomic patterns.

This study identifies 26 gut microbiome biomarkers associated with schizophrenia and links specific bacterial species, like Streptococcus vestibularis, to altered neurotransmitter levels and behavioral changes in mice.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

The paper shows glucocorticoids inhibit macrophage differentiation to a pro-inflammatory phenotype but not their migration in a zebrafish wound model.

The paper describes the discovery and characterization of a novel Klebsiella species, Klebsiella huaxiensis, isolated from a human urine sample.

This study uses a deep CNN to analyze lung cancer pathology images, identifies tumor shape features linked to survival, and develops a prognostic model validated in an independent cohort.

The paper develops and validates a nomogram prognostic model for small-cell lung cancer patients using clinical data from the National Cancer Database.