Y. Xie

The paper investigates age-dependent H3K9 acetylation changes in rice flag leaf senescence, finding increased H3K9ac levels correlate with gene expression and identify regulatory networks.

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

The paper identifies Kin17 as a regulator of Miranda localization in Drosophila neuroblasts by promoting splicing of Falafel, a PP4 component, ensuring proper basal localization of Miranda during asymmetric division.

The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.

This study identifies natural killer-like B cells as pathogenic in rheumatoid arthritis by promoting Th17 differentiation and disease severity.

The paper identifies extrachromosomal HPV16 episomes as a mechanism of cervical carcinogenesis, showing that they can cause cancer without integration through rearranged and multimer episomes.

This study shows that flagellin FLiC enhances upland cotton resistance to Verticillium dahliae by inducing immune responses and modulating calcium, hydrogen peroxide, and nitric oxide pathways.

This study shows that OXPHOS enhances TH17 cell survival and persistence by promoting mitochondrial fitness and anti-apoptotic markers.

This paper identifies a monoclonal antibody, 2G1, that neutralizes all SARS-CoV-2 variants with high potency and describes its mechanism of action and therapeutic efficacy in animal models.

This study examines how nutrient enrichment and herbivory by an invasive snail interactively affect growth of an invasive macrophyte and native macrophytes in freshwater mesocosms.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This paper develops a deep learning system to assess upper airway obstruction and adenoid size in pediatric radiographs, achieving good segmentation performance and agreement with experts.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

This study reports cryo-EM structures of Ubr1 complexes to elucidate the mechanism of ubiquitination initiation and elongation using a single E2 enzyme.

This study identifies TFAM3 as a regulator of shoot meristem maturation in plants, showing that ALOG family proteins form transcriptional condensates to control flowering timing and inflorescence architecture.

This study shows BCOR and BCORL1 mutations disrupt PRC1.1 function in leukemia by separating its enzymatic core from chromatin targets, leading to treatment resistance.

This paper analyzes tourism land use changes and their influencing factors in Luanchuan County, China, using land use data and binary logistic regression.

The paper shows that FGFR inhibitors cause SWI/SNF complex dismissal from YAP-dependent enhancers, leading to adaptive resistance in TNBC through epigenetic and metabolic changes.

This study examines genome-wide transcriptional responses of marine nematode Litoditis marina to hyposaline and hypersaline stresses, identifying conserved and specific gene expression patterns.

This study shows R13, a TrkB agonist, improves mitochondrial function and reduces AD-related pathology in 5xFAD mice by enhancing biogenesis and metabolism.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

This study presents cryo-EM structures of human p97 complex with and without inhibitor NMS-873, revealing conformational changes and allosteric inhibition mechanisms.

The paper presents a cryo-EM structure of the yeast THO*Sub2 complex and shows its interaction with the SR-like protein Gbp2, suggesting a role in mRNP maturation.

This study investigates a fermented Yi traditional medicine, JB10, showing significant in vitro suppression of SARS-CoV-2 replication with EC50 of 769.1 dilutions and a selection index of 42.68.

This study develops engineered red blood cells expressing a PCSK9 inhibitor to lower LDL and prevent obesity in mice.

The paper reports cryo-EM structures of SARS-CoV-2 RdRp with nucleoside inhibitors, revealing their mechanism and guiding the design of more potent derivatives.

The paper introduces a generative model to test hypotheses about cell-cell interactions in tumor microenvironments using synthetic multiplexed images.

This study identifies sAB-K29, a tool to detect K29-linked polyubiquitin, and shows its role in proteotoxic stress response and cell cycle regulation.

The paper identifies species-specific genetic differences in ACE2 that determine SARS-CoV-2 entry capability and shows that humanizing these residues in koala and mouse ACE2 enables viral entry.