Y. Yang

This study shows olanzapine induces NAFLD via the apoA5 pathway by increasing hepatic apoA5 protein and sortilin levels, with APOA5 knockdown reversing steatosis.

This study characterizes the airway bacterial and fungal microbiome in COPD patients and healthy controls, finding altered microbial diversity and interactions associated with disease severity.

This paper develops a chemiluminescence immunoassay for detecting ASFV antibodies in serum, showing high specificity, sensitivity, and consistency with a commercial kit.

This study identifies a hypervirulent CRKP strain in Egypt carrying two plasmids with carbapenemase and virulence genes, highlighting the genetic basis of resistance and virulence.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

This paper introduces a deep learning method to improve light-field microscopy, enabling high-speed, artifact-free volumetric imaging of biological processes.

REAP identifies autoantibodies targeting the human exoproteome by screening patient samples against a yeast-displayed extracellular protein library, revealing known and novel reactivities in autoimmune diseases.

This study shows archaeal extracellular vesicles, produced via ESCRT machinery, transfer DNA and support nutrient cycling in extreme environments.

This paper develops a mucosal RSV vaccine, P-KFD1, which protects mice against RSV infection without vaccine-enhanced disease and relies on CD4+ T cell responses mediated by IFN-γ or IL-17A.

This study identifies TiAP1 from Thinopyrum intermedium as a resistance gene against Blumeria graminis f. sp. tritici, showing it interacts with BgtCDA1 and enhances wheat resistance through immune activation.

This study identifies exosomal miR-130a-3p from acinar cells as a regulator of pancreatic fibrosis by targeting PPAR-γ in stellate cells, showing its role in collagen formation and fibrosis progression.

This study examines fungal co-occurrence networks along an elevation gradient on Mt. Norikura, finding that climate factors dominate network connectivity patterns, with significant declines between 700 m and 1500 m elevation.

The paper establishes a SARS-CoV-2 lentiviral pseudovirus neutralization assay using 293T cells expressing ACE2 and TMPRSS2, showing good correlation with other assays.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This study finds a significant association between Kaposi's Sarcoma Herpesvirus (KSHV) infection and osteosarcoma in the Xinjiang Uyghur population, identifying KSHV as a potential risk factor and a newly identified viral-associated cancer.

The paper determines high-resolution structures of outer-arm dynein arrays bound to microtubule doublets, revealing a mechanism for motor coordination through ATP hydrolysis and tail-to-head interactions.

This study links CD44-/CD24- breast cancer cells to late-stage tumor recurrence and identifies RHBDL2 as a regulator of CSC conversion.

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

This study examines seasonal variations in soil fungal communities and co-occurrence networks along an altitudinal gradient in a cold temperate zone, finding that altitude has stronger effects than season on community structure and diversity.

This study identifies 36 upregulated genes across SARS-CoV-2-infected respiratory tract cells, highlighting inflammatory and interferon response pathways linked to cytokine storms in severe COVID-19.

This paper introduces GETMap, a method to determine tissue origin of plasma DNA carrying genetic variants, validated across prenatal testing, transplantation, and oncology scenarios.

The paper investigates mtDNA variants in human polar bodies and mouse oocytes, showing meiotic selection removes defective mitochondria.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

This study shows that dysfunction of IBM1 in Arabidopsis changes root-associated bacteria communities by altering microbial family abundances in both rhizosphere and endosphere.

This study investigates how Alisertib affects KRAS mutations in colorectal cancer cells, showing allele-specific effects on RAS signaling and cell death mechanisms.

This study identifies exosomal lncRNA PICALM-AU1 from cholangiocytes as a key regulator of endothelial-mesenchymal transition in hepatopulmonary syndrome, with potential as a biomarker and therapeutic target.

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

This study identifies two efficient multiplex genome editing tools for Phalaenopsis orchids using a protoplast platform, with DPII-Cpf1 showing the highest editing efficiency.

This study analyzes the transcriptome of potato leaves infected with Alternaria solani to identify gene expression changes and hormone responses associated with disease resistance.