Y. Zhao

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study shows that endothelial PHD2 deficiency leads to nitrative stress via suppression of Caveolin-1, contributing to pulmonary arterial hypertension and vascular remodeling.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

The paper tests the Fishers Geometric Model postulate by analyzing gene expression data, showing that small-step evolution via miRNA regulation is common but does not lead to long-term phenotypic changes.

The paper was withdrawn due to insufficient cell culture data to clarify the mechanism of ticagrelor and aspirin's effect on the gut microbiome and immuno-inflammatory response in atherosclerosis.

This study uses deep learning to predict neoadjuvant chemotherapy benefit in breast cancer using stromal histology, introducing the TS-score which outperforms existing predictors.

This study identifies Pygo2 as a driver oncogene in prostate cancer that suppresses immune infiltration and response to immunotherapy, showing that its inhibition enhances anti-tumor immunity.

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

The paper identifies GM-CSF-producing T cells that drive glomerulonephritis by licensing monocyte-derived cells to produce MMP12, leading to renal tissue damage.

This study identifies how SARS-CoV-2 S protein inhibits type I interferon signaling by interacting with and reducing phosphorylation of STAT1/STAT2, preventing ISGF3 complex formation and ISG expression.

This study identifies the molecular mechanism of root halotropism in Arabidopsis, showing that ABA-mediated microtubule reorientation drives anisotropic cell expansion and root twisting in response to salt stress.

This study shows Lis1 binding to dynein affects force-induced detachment asymmetry and slows dynein movement without altering stall forces.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

The paper reanalyzes PANDORA-seq data to show 28s5-rtsRNA is abundant and functions with 5.8s rRNA-derived small RNA to reduce ribosomal protein mRNA levels, with key nucleotides identified through mutational scanning.

The paper uses bipartite network analysis to study how mathematics is integrated into marine biology education, identifying patterns and challenges in interdisciplinary teaching.

This study uses GDNF-loaded extracellular vesicles from macrophages to treat Parkinson's disease, showing improved mobility and reduced neuroinflammation in mice.

This study identifies USP11 as a deubiquitinase that stabilizes HINT3, promoting endothelial apoptosis-resistance in pulmonary hypertension.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

The paper introduces MAGNIFIERS, a technique combining SRS microscopy with expansion microscopy to achieve sub-50 nm resolution and scalable multiplexity for label-free chemical imaging.

The paper quantifies the diffusive dynamics of multiheme cytochromes in Shewanella oneidensis MR-1 using single-particle tracking and shows their role in long-distance electron transport.

This study identifies how flavivirus prM proteins interact with MDA5 and MAVS to inhibit RLR antiviral signaling, revealing species-dependent immune evasion mechanisms.

This study uses a transgenic mouse model to show that sustained HOTAIR expression promotes breast cancer metastasis and that its removal reverses metastatic traits, indicating an erasable epigenetic memory.

This study uses a LNA/DNA nanobiosensor to analyze Dll4 mRNA dynamics during osteogenic differentiation of hMSCs in 2D and 3D environments, showing Notch1-Dll4 signaling regulates osteogenesis and is active during differentiation.

This study examines how aging and frailty affect platelet function before and after influenza vaccination, revealing age-related changes in activation and translation.

The paper visualizes the tubulin folding pathway mediated by TRiC using cryoEM, showing how TRiC's structure guides the folding of β-tubulin through specific interactions.

The paper investigates how acetylation reading and writing enable long-range chromosomal interactions through the BRD4-NUT oncogenic fusion protein and p300 activation.

This study identifies HERV activation in BA livers and shows it re-educates macrophages, impairing neutrophil recruitment and causing liver damage, suggesting therapeutic targets.

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.