Y. Zhao

This study evaluates whether a unified model can predict plant and leaf parameters of winter wheat using vegetation indices across growing seasons, finding that hierarchical linear models (HLM) are stable and applicable across seasons for most parameters.

This study develops a chimeric mRNA vaccine that provides broad protection against Omicron and Delta variants of SARS-CoV-2 by combining RBDs from different variants.

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

This study uses urine single cell RNA-sequencing to identify inflammatory signatures in immune cells and podocytes in FSGS, suggesting potential for non-invasive diagnosis and biomarker discovery.

The paper analyzes the expansion and adaptive evolution of mTERF genes in plants, finding that M-class mTERF genes expanded via tandem duplication and evolved rapidly with positive selection in nucleic acid-binding sites.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

This paper develops two new strategies for constructing large variant DMS libraries in mammalian cells using piggyBac-mediated genomic integration and in-vitro ligation.

This study identifies hypoxia-regulated ubiquitination of DBC1 by SIAH2 and OTUD5 as a mechanism driving breast cancer progression.

The paper redescribes Conicula striata as a stem medusozoan with features of both anthozoans and medusozoans, suggesting an anemone-like ancestor for medusozoan cnidarians.

This study identifies two distinct binding modes of RbFox's RNA Recognition Motif that contribute to its high sequence specificity and functional diversity.

This study constructs a pan-vaccine (S6) based on the evolutionary patterns of SARS-CoV-2 spike protein to combat diverse variants, showing broader neutralization than existing vaccines.

This study maps 3D genome reorganization during skeletal muscle stem cell activation, proliferation, and aging using Hi-C, revealing how chromatin architecture influences gene expression and lineage progression.

The paper tests neutralization activity of sera from convalescents and vaccine recipients against Omicron, finding that vaccines maintain better neutralization than convalescents.

This study identifies MIG-23 as a key regulator of sperm migration in Ascaris suum by modulating extracellular ATP levels through ecto-ATPase activity.

The paper describes a self-assessment process to improve lab culture through surveys and group discussions, resulting in a 12% increase in member satisfaction.

The paper introduces dExPath, an expansion microscopy variant that improves immunostaining in human brain pathology specimens by expanding proteins and reducing autofluorescence, revealing previously invisible disease markers.

This study constructs a single-cell atlas of liver cancer tumor clonality using machine learning and identifies osteopontin as a key driver of tumor evolution and immune reprogramming.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study identifies multiple SARS-CoV-2 receptors, including ASGR1 and KREMEN1, which enable virus entry and correlate with multi-organ tropism and clinical symptoms.

This study shows that loss of endothelial PHD2 causes cardiac hypertrophy and fibrosis via HIF-2, and PHD2 is reduced in human cardiomyopathy.

The paper analyzes SARS-CoV-2 genome sequences to show mutation sweeps driven by emerging variants, which may prolong the pandemic and challenge control efforts.

The paper presents a cryo-EM structure of the inner ring subunit from Xenopus laevis NPC, revealing its composition and interactions.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study shows Parkin promotes AKT degradation during mitophagy, while USP30 protects AKT, influencing cell apoptosis and USP30's broader physiological roles.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

This study introduces scStereo-seq, a method for single-cell spatial transcriptome profiling in Arabidopsis leaves, revealing cell type-specific spatial gene expression gradients and developmental trajectories.

This study inhibits the auxin inactivation pathway using a novel chemical inhibitor, revealing rapid auxin turnover and dynamic regulation of auxin homeostasis.

This study identifies CsMYB4a as a multifunctional transcription factor that regulates the auxin signaling pathway and phenylpropane/lignin pathways in Camellia sinensis.

This study shows that human cord blood-derived stem cells suppress B-cell activation via a Gal-9-dependent cell contact mechanism and affect calcium levels and signaling pathways.