Z. Wu

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

This study identifies NRG1C, an N-terminally truncated helper NLR in Arabidopsis, which antagonizes immunity mediated by its full-length relatives NRG1A and NRG1B.

This study identifies ERK1/2-mediated phosphorylation of NRF1 as critical for proteasome production and stress resistance, showing therapeutic potential in cancer.

This study shows that TIR signaling is essential for enhancing plant defense during pattern-triggered immunity by activating defense genes and increasing resistance to pathogens.

The paper uses cryo-EM and deep learning to analyze human 26S proteasome conformers, revealing dynamics of ubiquitin-mediated autoregulation during substrate degradation.

This paper identifies a shared trans flavin-dependent assembly line for 2,2-bipyridine formation in caerulomycin and collismycin antibiotics, revealing sulfur fate differentiation through differential sulfhydryl group treatment.

This study identifies RaACE2 as a functional receptor for SARS-CoV-2 and RaTG13, and evaluates ACE2s from 16 species for their ability to mediate virus entry.

This study identifies capsule switch in Streptococcus suis strains through comparative genomic analyses, revealing genetic exchange between SS2, SS3, and SS7 strains.

The paper shows that the KDEL receptor uses pH to strengthen a short hydrogen bond, enhancing peptide binding and enabling COPI-mediated retrieval of ER proteins.

This study shows that inhibiting PLK1 promotes reactivation of KSHV and EBV in B-cell lymphomas, leading to cell death, and identifies PLK1 as a potential therapeutic target for HIV-positive patients.

This study shows heat stress inhibits meiotic recombination in Arabidopsis by reducing DSB formation and homolog synapsis, affecting chromosome axis stability and recombinase levels.

This study reveals the molecular architecture of the SARS-CoV-2 virus using cryo-ET and STA, showing the structure of S proteins, N-linked glycans, and RNPs.

This study identifies Il13 enhancers that mediate gene transcription in response to antigenic stimulation by analyzing histone modifications and transcription factor binding sites.

This study shows that IgT is the main immunoglobulin induced in trout skin mucosa during bacterial infection, with SALT serving as a key inductive site.

This paper develops an acoustofluidic method to controllably fuse human brain organoids, enhancing standardization and reproducibility of fused models.

This study shows that excessive polyamine production in keratinocytes drives self-RNA sensing by dendritic cells, contributing to psoriasis inflammation.

This paper creates a single-cell transcriptomic atlas of the Chinese horseshoe bat to study its role as a viral reservoir, identifying cell types and receptor expression patterns related to viral entry.

This paper introduces a method to detect O-GlcNAc modifications using tandem glycan labeling and fluorescent detection, showing HIF1α as an O-GlcNAc target.

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study shows indomethacin inhibits SARS-CoV-2 pseudovirus in vitro and accelerates recovery in CCV-infected dogs compared to ribavirin.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

This paper introduces an acoustofluidic device to create 3D neurospheroids for modeling Alzheimer's disease neuroinflammation and amyloid-β toxicity.

The paper designs novel covalent inhibitors against SARS-CoV-2 using a deep Q-learning network and fragment-based drug design, generating 47 lead compounds available in a public repository.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This paper introduces a DNA-brick assisted centrifugation method to sort liposomes by size, enabling the study of membrane curvature effects on protein activity.

This paper develops a microfluidic platform to assemble human brain organoids and models prenatal cannabis exposure effects on early brain development.

The paper assesses changes in drifting fish egg composition and abundance in the Xijiang River after dam construction, linking these changes to environmental factors.