C. Huang

This study shows that SARS-CoV-2 ORF7 increases monocyte chemotaxis via CCL2 and decreases neutrophil recruitment via reduced IL-8.

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

This study investigates the cardiac electrophysiological effects of hydroxychloroquine and azithromycin, showing they prolong QT intervals and increase arrhythmia risk when combined.

The paper reveals how assembly status transitions in glutamine synthetase modulate enzymatic activity through dynamic allosteric regulation.

The paper identifies MOV10 as a new m6A-reader that facilitates mRNA decay via m6A to regulate the WNT/β-CATENIN pathway and maintain mouse embryonic stem cell state.

This study compares MRSA populations from Chinese pig farms and hospitals, finding distinct human and animal lineages with different genetic features and no evidence of spillover from farms to humans.

This paper develops a machine learning tool called STEP3 to accurately define bacteriophage virion components using evolutionary features, validated with mass spectrometry.

This study shows Mycobacterium smegmatis resists carbon monoxide by using cytochrome bd oxidase and shows minimal proteomic changes.

This study shows that truncating the SARS-CoV-2 Spike protein's cytoplasmic tail increases pseudovector titer but masks the D614G mutation's effect on Spike incorporation.

This study shows that substrate stiffness affects the adherence of EAEC bacteria to human intestinal enteroids, with softer hydrogels promoting larger bacterial aggregates.

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

This study evaluates the neutralization capacity of hyperimmune immunoglobulins and convalescent plasma against SARS-CoV-2 and its variants, finding reduced effectiveness against certain variants with hCoV-2IG showing better cross-neutralization than convalescent plasma.

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

This paper determines the cryo-EM structure of full-length NF1, revealing its autoinhibited conformation and providing insights into disease mechanisms and therapeutic strategies.

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

This study shows that elongated Lpp in E. coli counteracts periplasmic enlargement through homeostatic mechanisms involving Lpp tilting and abundance reduction, impacting cell envelope processes and viability.

This study shows that disrupting FGF2 enhances thermogenesis in brown and beige fat, reducing obesity and hepatic steatosis in mice.

This study identifies three novel Arthrobacter phages that show close functional relationships with Microbacterium phages, highlighting the need for multiple metrics to assess phage relatedness.

This study identifies an IL1β/NFκB/ESE3 signaling axis in pancreatic stellate cells that drives fibrosis, chemoresistance, and poor prognosis in pancreatic cancer.

This paper applies multi-task learning to automate 3D striatal segmentation in MRI, achieving results comparable to manual segmentation with high Dice similarity and correlation metrics.

This study shows that blood collection tubes affect biomarker screening results in mass spectrometry, with coagulant tubes altering protein profiles and reducing biomarker detection.

This study compares the Accula SARS-CoV-2 POC test with a lab-developed assay, finding high negative agreement but lower positive agreement for low viral load samples.

This study examines how Ursolic acid affects intestinal microbiota in liver fibrosis mice, finding improved microbial diversity and function in treated animals.

The paper investigates the PTEN:P-Rex2 complex, identifying how cancer mutations disrupt its inhibitory function and hyperactivate Rac1 signaling.

This study shows that the IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro by reducing viral titers by up to 4 logs after overnight pretreatment.

This study shows that Type I interferons significantly reduce SARS-CoV-2 viral titers in Vero cells, with IFN-β being more effective than IFN.

This study shows that glycyrrhizic acid improves cognitive function in aged mice by enhancing T and B cell proliferation and blood perfusion.

The paper introduces an efficient long fragment editing technique for scarless genome engineering in E. coli, enabling large-scale DNA insertion and deletion with high success rates.

This study shows that restricting essential amino acids, not non-essential ones, drives systemic metabolic responses to dietary protein dilution and genetic amino acid transport loss.