C. Zhao

This study identifies urine proteome changes in a rat model of simvastatin-induced skeletal muscle injury, highlighting potential biomarkers for SAMS.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows IDH3B is essential for spermiogenesis but not retinal health, as Idh3b-knockout mice are infertile but have normal vision.

This study identifies hedgehogs as the major amplifying hosts of SFTSV, showing they can sustain viral transmission cycles with ticks in both laboratory and natural settings.

This study identifies ACE2 as the receptor for NeoCoV and PDF-2180-CoV, two close MERS-CoV relatives in bats, showing they can use bat ACE2 and, with mutation, human ACE2.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

This study shows pVHL regulates TCF/LEF protein stability via ubiquitin-independent proteasomal degradation, revealing a novel mechanism in Wnt/β-catenin signaling.

This study uses molecular dynamics simulations to show that water displacement at plant hormone receptor binding sites affects binding free energy and provides insights for agrochemical design.

This study shows that Malus baccata contributes to the genomes of cultivated European and Chinese apples through gene flow, alongside Malus sylvestris and Malus sieversii.

This study shows that late gestation transient prenatal hypoxia in mice leads to long-term functional deficits without gross anatomical brain damage.

This study examines age-related cellular changes in the rotator cuff enthesis of rats, finding increased mineralization and reduced tenogenic and chondrogenic potential in aged cells.

This study identifies a γδ IEL hyperproliferative phenotype influenced by the intestinal microbiota, which enhances protection against bacterial infection.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The paper reports cryo-EM structures of human TMEM120A and TMEM120B, revealing similar dimeric assemblies but no structural basis for their differing mechanosensing properties.

This paper characterizes a glycolipid glycosyltransferase (GTcp) from Candidatus Pelagibacter sp. HTCC7211, showing its broad substrate specificity and role in glycoglycerolipid synthesis under phosphorus stress.

The paper develops a synthetic infection microbiome model to show antibiotics can drive expansion of rare pathogens through competitive release in chronic infections.

This paper introduces SNU-seq, a method for single-nucleotide uracil mapping in DNA, validated on synthetic DNA and mammalian genomes, revealing uracil dynamics in treated cells and AID hotspots.

This study shows TRAF2 regulates mitophagy and inflammation in cardiac myocytes to prevent cell death and maintain homeostasis.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This paper shows that Pseudomonas aeruginosa produces novel glycolipids under phosphorus stress, which protect it from polymyxin B antibiotic.

This study uses molecular dynamics simulations to explain how ABA activates and causes dissociation of dimeric PYL2 receptors and their interaction with HAB1 phosphatase.

This study identifies unbalanced dietary patterns as contributors to precocious puberty by altering gut microbiota and host metabolites, with biomarkers showing high diagnostic accuracy.

This study evaluates S-Trimer, a subunit vaccine candidate for COVID-19, showing it induces protective immunity in nonhuman primates with adjuvants.

The paper characterizes 44 Arabidopsis UMAMITs, showing their localization and function as amino acid exporters, providing insights into their evolutionary role and transport properties.

This paper develops a PET probe for subtype-selective V1A receptor imaging in peripheral organs, showing high affinity and selectivity for V1A over other vasopressin receptors.

The paper shows that inhibiting HSP90 reduces STAT3-mediated muscle wasting in cancer cachexia by disrupting the HSP90/STAT3/FOXO1 axis.

The paper shows that CSP reduces ATG levels via ubiquitination by NEDD4, enabling EEFs to evade IFN-gamma-mediated killing in hepatocytes.

This paper demonstrates that SHIVs with bulky aromatic amino acid substitutions at Env375 replicate efficiently in rhesus macaques and can be used for preclinical HIV vaccine testing.

This study uses fMRI to show that amblyopia causes layer-specific changes in subcortical visual pathways, with reduced feedforward signals in the geniculostriate pathway and altered feedback signals in the retinotectal pathway.