J. Lin

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

The paper identifies CDK12 inhibition as a strategy to enhance EGFR blockade efficacy in TNBC by targeting translation and stability of oncoproteins like MYC through 4E-BP1 and CCR4-NOT complex.

The paper analyzes T-cell receptor repertoires in different phases of COVID-19 to identify immune response patterns and predict recurrent infection risk.

This study shows that in Escherichia coli, replication and division are strongly correlated at slow growth rates but become independent at higher growth rates.

This study uses single-cell RNA sequencing to analyze aging-related changes in subcutaneous adipose tissue, revealing shifts in cellular roles and metabolic phenotypes associated with aging.

The paper identifies a novel antiviral chemotype effective against multiple respiratory viruses by targeting a host multi-protein complex involved in viral lifecycle and innate immunity.

This study develops process-based tree phenology models for subtropical trees using experimental data, showing advanced spring phenology under warming with species-specific responses.

The paper identifies two transcription factors, RlmA and Ace1, critical for Aspergillus fumigatus virulence by analyzing gene expression during lung infection in mice.

This study combines CRISPR activation and binary colloidal crystals to enhance the rapid differentiation of human iPSCs into neurons.

This study determines the structure of the Bax core dimer and shows it forms part of the mitochondrial pore wall during apoptosis.

This study identifies the SiaABC threonine phosphorylation pathway as a regulator of biofilm formation in Pseudomonas aeruginosa in response to carbon availability and surfactant stress.

This study shows that C. elegans uses mitochondrial surveillance systems and the AMPK pathway to trigger innate immune responses against bacterial pathogens through non-PRR patterns.

This study examines how wildfire and its legacy through charcoals affect soil microbial communities in boreal forests over a 29-year chronosequence.

This study investigates the radiosensitizing effect of curcumin combined with Glu-GNPs on breast cancer xenografts in nude mice, showing reduced VEGF and HSP90 expression.

This study reveals how target RNA binding regulates Cmr-β complex activities through conformational changes, enabling immune responses against genetic invaders.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study investigates how Candida albicans virulence factors Als3 and Ece1/Candidalysin interact with host receptors EphA2 and EGFR to induce inflammation during oropharyngeal candidiasis.

The paper shows that IMD/Relish suppresses perilipin1, leading to lipid droplet enlargement that reduces ROS stress during bacterial infection in Drosophila.

This study tracks clonal evolution in residual breast cancer tumors and finds that recurrence can arise through distinct evolutionary paths with different clonal compositions and drug sensitivities.

This paper isolates blocking antibodies against SARS-CoV-2 RBD using a competitive biopanning strategy, identifying a high-affinity antibody with potent neutralizing activity.

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.

This study shows P4HA2 is overexpressed in glioma and promotes cancer progression by enhancing proliferation, invasion, migration, and EMT, while also regulating the PI3K/AKT pathway through collagen expression.

This study shows that Bacillus subtilis spore enhances mucosal immunity by promoting intestinal-resident memory T cells through ICAM-1 expression on dendritic cells.

The paper identifies the genetic basis of sex determination in grapevines by analyzing phased genomes and finding a novel male-fertility gene.

This study shows that reducing SIRT2 rescues GARS-induced neuropathy in a Drosophila model by restoring acetylated tubulin levels and axonal transport.

This study investigates how microbial growth traits evolve under serial dilution, finding that growth rate and lag time are subject to selection while yield is not.

This study determines high-resolution structures of E. coli ClpAP complex in substrate-bound states to elucidate the mechanism of protein unfolding and proteolysis coupling.

This study shows anlotinib inhibits drug-resistant colorectal cancer cell proliferation and induces apoptosis by inactivating the PI3K/AKT pathway.