Author
J. Lin
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2016-2024 · peak 24/yrCo-Author Collaboration Network
10 top collaborators · 17 mutual co-author links106 papers
Recent·Most cited
- Cell BiologybioRxiv
Gaq-PKD/PKCμ regulates the IkB transcription to limit the NF-kB mediated inflammatory response essential for early pregnancy
Y. Jiang, Y. He, S. Liu…·G. Shi
This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.
DOI 10.7554/elife.83083 - Animal Behavior & CognitionbioRxivPreprint
Masking effects on Iso-valeric Acid Recognition by Sub-threshold Odor Mixture
J. Huang, J. Lin, R. Yeung…·T. E. Acree
The paper investigates how sub-threshold odor mixtures mask the unpleasant smell of iso-valeric acid using Sniff Olfactometry, finding that mixtures reduce recognition by up to 96%.
DOI 10.1101/2022.10.13.512096 - MicrobiologybioRxivPreprint
Brevicidine, a bacterial non-ribosomally produced cyclic antimicrobial lipopeptide with a unique modus operandi
X. Zhao, X. Zhong, H. Wan…·O. P. Kuipers
This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.
DOI 10.1101/2022.10.07.511251 - Cancer BiologybioRxiv
Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy
A. F. Lingappa, O. Akintunde, C. Ewald…·V. R. Lingappa
The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.
- Plant BiologybioRxivPreprint
Distinct selection signatures during domestication and improvement in crops: a tale of two genes in mungbean
Y.-P. Lin, H.-W. Chen, P.-M. Yeh…·C.-R. Lee
This study compares selection signatures in mungbean domestication and improvement, identifying distinct genomic footprints associated with different genes and selective pressures.
DOI 10.1101/2022.09.08.506689 - MicrobiologybioRxivPreprint
Dual control of lysogeny and phage defense by a phosphorylation-based toxin/antitoxin system
Y. Guo, K. Tang, B. Sit…·X. Wang
This paper identifies a phosphorylation-based toxin/antitoxin system in Pseudomonas aeruginosa that regulates prophage activation and defends against lytic phages.
DOI 10.1101/2022.09.05.506569 - Plant BiologybioRxivPreprint
Brassinosteroids signaling component SlBZR1 promotes fruit ripening in tomato
F. Meng, H. Liu, S. Hu…·Q. Wang
This study shows that brassinosteroids promote tomato fruit ripening by enhancing ethylene production and carotenoid accumulation through the SlBZR1 transcription factor.
DOI 10.1101/2022.07.11.499596 - Pharmacology & ToxicologybioRxiv
A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes
Y. Wang, D. Wang, J. Lin…·K. Zhang
This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.
DOI 10.1002/anie.202204576 - MicrobiologybioRxiv
An atypical F-actin capping protein modulates cytoskeleton behaviors crucial to colonization of Trichomonas vaginalis
K.-H. Wang, J.-Y. Chang, F.-A. Li…·H.-M. Hsu
This study identifies an atypical F-actin capping protein in Trichomonas vaginalis that modulates cytoskeleton dynamics through phosphorylation, essential for host colonization.
DOI 10.1128/spectrum.00596-23 - BiochemistrybioRxivPreprint
A molecular plugin rescues GroEL/ES substrates from pre-folding oxidation
E. Dupuy, S. Van der Verren, J. Lin…·J.-F. Collet
This study identifies CnoX as a redox quality-control plugin for GroEL, showing it binds outside the substrate-binding site and forms mixed-disulfides with substrates.
DOI 10.1101/2022.05.03.490446 - MicrobiologybioRxivPreprint
Hinokitiol alters Gene Expression in Aspergillus fumigatus, protects against fungal keratitis by Reducing Fungal Load, LOX-1, Proinflammatory cytokines and Neutrophil Infiltration
S. Ma, H. Lin, X. Peng…·J. Lin
This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.
DOI 10.1101/2022.02.18.480984 - BiochemistrybioRxiv
DJ-1 glyoxalase activity makes a modest contribution to cellular defense against methylglyoxal damage in neurons
M. C. Mazza, S. Shuck, J. Lin…·M. A. Wilson
This study investigates DJ-1's role in glycation defense and finds it has only a minor effect on reducing methylglyoxal damage in neurons.
DOI 10.1111/jnc.15656 - BiophysicsbioRxivPreprint
Elasticity generates indissoluble biomolecular condensates
This study shows elasticity prevents biomolecular condensates from dissolving by establishing a mechanical equilibrium and predicting a phase diagram for indissolubility.
DOI 10.1101/2022.02.09.479808 - MicrobiologybioRxivPreprint
Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth
This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.
DOI 10.1101/2022.02.01.478504 - Cancer BiologybioRxivPreprint
Single-Cell Transcriptomic Analyses of Tumor Ecosystems and Spatial Architectures in Human Small Cell Lung Cancers
H. Ouyang, J. Chen, C. Xu…·D. Jia
This study uses single-cell and spatial transcriptomics to analyze heterogeneity and immunosuppressive microenvironment in human SCLC, identifying hybrid tumor cell states and their origins.
- ImmunologybioRxivPreprint
Longitudinal Assessment of SARS-CoV-2 Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multi-Cytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity
J. Lin, R. Law, C. Korosec…·M. Ostrowski
This study tracks SARS-CoV-2-specific T cell cytokine responses over one year, finding persistent multi-cytokine production with greater immunity linked to disease severity.
DOI 10.1101/2022.01.18.476864 - Cancer BiologybioRxivPreprint
Metabolitin-based molecular drug delivery by targeting GPR158 in glioblastoma
H. Zhao, W. Zhu, J. Li…·J. Zhang
This study develops a metabolitin-based drug delivery system targeting GPR158 in glioblastoma, showing BBB penetration and anti-tumor effects in vitro and in vivo.
DOI 10.1101/2021.12.13.472376 - ImmunologybioRxiv
Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells
D. Huang, J. Li, F. Hu…·J. Wang
This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.
DOI 10.1038/s41421-022-00467-2 - MicrobiologybioRxiv
Metabolite Damage and Damage-Control in a Minimal Genome
D. Haas, A. M. Thamm, J. Sun…·V. de Crecy-Lagard
The paper identifies and validates genes involved in metabolite damage repair and preemption in the minimized Mycoplasma JCVI-Syn3A genome and extends its metabolic map.
DOI 10.1128/mbio.01630-22 - Cell BiologybioRxiv
OxPhos Dysfunction Causes Hypermetabolism and Reduces Lifespan in Cells and in Patients with Mitochondrial Diseases
G. Sturm, K. R. Karan, A. Monzel…·M. Picard
The paper shows that OxPhos dysfunction leads to hypermetabolism and reduced lifespan in cells and mitochondrial disease patients.
DOI 10.1038/s42003-022-04303-x - Cell BiologybioRxiv
A Multi-Omics and Bioenergetics Longitudinal Aging Dataset in Primary Human Fibroblasts with Mitochondrial Perturbations
G. Sturm, A. S. Monzel, K. R. Karan…·M. Picard
The paper presents a longitudinal multi-omics dataset of human fibroblasts with mitochondrial perturbations to study aging mechanisms and bioenergetics.
DOI 10.1038/s41597-022-01852-y - BioengineeringbioRxivPreprint
High Resolution Nanostructure with Two-stages of Exponential Energy Dissipation at the Ultrathin Osteochondral Interface Tissue of Human Knee Joint
X. Wang, J. Lin, Z. Li…·O. Hongwei
The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.
DOI 10.1101/2021.10.18.464899 - MicrobiologybioRxivPreprint
Identification of Serum Bridging Molecules that Mediate Human Endothelial Cell Invasion by Candida species
Q. T. Phan, N. V. Solis, J. Lin…·S. G. Filler
This paper identifies serum proteins that mediate endothelial cell invasion by non-C. albicans Candida species through bridging molecule-mediated endocytosis.
DOI 10.1101/2021.09.18.460925 - BiochemistrybioRxivPreprint
Divining Deamidation and Isomerization in Therapeutic Proteins: Effect of Neighboring Residue
F. J. Irudayanathan, J. Zarzar, J. Lin, S. Izadi
This study identifies key molecular indicators of asparagine deamidation and aspartic acid isomerization in therapeutic antibodies and proposes a physics-based model to predict their propensity.
DOI 10.1101/2021.07.26.453885 - BiophysicsbioRxiv
Annealing synchronizes the 70S ribosome into a minimum-energy conformation
X. Chu, X. Su, M. Liu…·Q. Shen
This paper demonstrates that annealing the 70S ribosome at a fast cooling rate synchronizes it into a minimum-energy conformation, enhancing homogeneity and stability for structural analysis.
DOI 10.1073/pnas.2111231119 - MicrobiologybioRxivPreprint
Exposure route, sex, and age influence disease outcome in a golden Syrian hamster model of SARS-CoV-2 infection
B. D. Griffin, B. M. Warner, M. Chan…·D. Kobasa
This study investigates how exposure route, sex, and age affect SARS-CoV-2 pathogenesis in golden Syrian hamsters, finding significant differences in disease outcomes.
DOI 10.1101/2021.06.12.448196 - MicrobiologybioRxiv
The globular C1q receptor is required for epidermal growth factor receptor signaling during Candida albicans infection
Q. T. Phan, J. Lin, N. V. Solis…·S. G. Filler
This study identifies proteins interacting with EGFR during C. albicans infection and shows that gC1qR is essential for EGFR signaling and immune responses.
DOI 10.1128/mbio.02716-21 - Cell BiologybioRxivPreprint
In vitro models of the human esophagus reveal ancestrally diverse response to injury
D. Ferrer-Torres, J. H. Wu, C. J. Zhang…·J. R. Spence
The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.
- Cell BiologyJournal of Cachexia, Sarcopenia and MusclePeer-reviewed
Transferrin receptor (Tfr1) ablation in satellite cells impacts skeletal muscle regeneration through the activation of ferroptosis
H. Ding, S. Chen, X. Pan…·L. Xie
Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.
DOI 10.1002/jcsm.12700