L. Lu

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

This study investigates SARS-CoV-2 transmission between minks and humans in the Netherlands, finding that some mutations led to faster and wider spread among mink farms.

The paper analyzes SARS-CoV-2 mutations and co-mutations, suggesting Canidae as a possible host for the B.1.1.7 variant and showing that co-mutations significantly reduce viral replication.

This study identifies the DEPDC1-EEF1A1-FOXO3a axis as a critical pathway promoting osteosarcoma progression by downregulating FOXO3a, with implications for therapeutic strategies.

This study shows that both increased and decreased SUMOylation enhance drought tolerance in apple by modulating MdDREB2A stability through SUMOylation and ubiquitination.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.

This study shows that apoptotic extracellular vesicles (apoEVs) protect liver homeostasis and regeneration by forming a chimeric organelle with the Golgi apparatus and restoring hepatic ploidy.

This study quantitatively examines how glycosyltransferases remain in the Golgi by analyzing their post-Golgi trafficking and identifying retention mechanisms through chimeric protein analysis.

This study evaluates enzalutamide's antiviral efficacy against SARS-CoV-2 in different cell types and mouse models, finding it effective in prostate cancer cells but not in lung cells or organoids.

The paper shows that MHC-II epitope removal from BCRs correlates with antibody development, T cell help, and long-term serum antibody secretion.

The paper tracks microbial communities over generations to show that strain-level interactions drive eco-evolutionary dynamics, with fine-scale genetic differences affecting community behavior.

This study investigates how epithelial colonies elongate in vitro, finding that global elongation results from cell elongation or oriented neighbor exchange depending on external stimuli.

The paper develops a genomic approach to identify public good exploiters in marine microbial communities degrading chitin, showing their activity and potential impact on polysaccharide degradation.

This study isolates and evaluates electroactive endophytic bacteria from plant tissues, identifying strains with potential for microbial fuel cells.

This paper develops flexible, transparent silver nanowire microelectrodes for multifunctional biointerfacing, showing high optical transparency, low impedance, and good biocompatibility in heart monitoring.

This study identifies and develops human SARS-CoV-2 neutralizing antibodies using a phage display library, showing their efficacy in vivo against the virus.

This study engineers a trimeric ACE2 protein that binds the spike protein with high affinity, inhibiting SARS-CoVs and mutants by locking the spike in a 'three-up' conformation.

This study shows that exogenous calcium is toxic to fungal cells lacking calcineurin, a key calcium regulator, and that this toxicity is linked to cytosolic calcium overload and vacuolar storage deficits.

The paper identifies genetic signatures for classifying HPV16, 18, 52, and 58 variants into lineages/sublineages with high accuracy using publicly available genomes.

This paper develops fully human single-domain antibodies against SARS-CoV-2 and identifies their neutralizing activity and immunogenic profile compared to SARS-CoV and MERS-CoV.

The paper introduces a quantitative metric and protocol to measure and correct fluorescence crosstalk in wide-field microscopy using common image processing software.

The paper shows that O- and N-glycans act as signals for Golgi export, affecting the trafficking of transmembrane proteins.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This paper presents a high-quality genome assembly of the Northern Cardinal and identifies candidate regulatory regions associated with red plumage coloration and sexual dichromatism.

This paper uses machine learning to identify motion features for evaluating rehabilitation progress in stroke patients, finding that movement smoothness is the best measure.

This paper identifies EK1C4, a potent fusion inhibitor against SARS-CoV-2 and other coronaviruses, showing high efficacy in vitro and in vivo.

This study shows that the SARS-CoV-specific antibody CR3022 binds strongly to 2019-nCoV RBD with a KD of 6.3 nM, while other antibodies targeting the ACE2 site fail to bind, highlighting the importance of RBD differences for cross-reactivity.

The paper investigates the evolutionary origins of epidemic potential in human RNA viruses, finding that most transmissible lineages evolved from non-human viruses.

The paper provides DNA barcodes for 1.5 million Canadian invertebrate specimens to improve taxonomic identification and biodiversity research.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.