M. Zhang

The paper introduces a post-processing method to enhance retinal image contrast by optimally combining multi-offset AO ophthalmoscope images.

This study identifies ginsenoside Rg3 as a molecular glue that enhances mitochondrial UPR via the TRKA-GRB2-EVI1-CRLS1 axis to restore proteostasis in Parkinson's disease.

The paper uses cryo-electron tomography to image mitochondria-cytoskeleton interfaces in mammalian sperm, revealing conserved supramolecular arrays composed of glycerol kinase-like proteins.

This study shows that SETD7 methylates KRAS at lysine 182 and 184, promoting its degradation and suppressing RAS/MEK/ERK signaling, thereby acting as a tumor suppressor in NSCLC.

This paper develops an integrated mass spectrometry strategy to analyze the complex glycosylation of erythropoietin, identifying N- and O-glycan structures and their site-specific modifications.

This study shows Bub1 and the CENP-U complex redundantly recruit Plk1 to kinetochores, ensuring accurate chromosome segregation, and suggests potential therapeutic targets for cancer cells with Bub1 or CENP-U mutations.

The paper introduces SPARCLD, a method for parallelized, multi-step liposome fusion using DNA, enabling high-throughput combinatorial screening with minimal material.

This study identifies SlBES1 as a regulator of tomato fruit softening by repressing PMEU1, leading to firmer fruits with extended shelf life without affecting visual or nutritional quality.

This study analyzes the spatio-temporal changes in Nanjing's urban thermal environment from 2014 to 2018 and identifies key driving factors behind these changes.

This study shows that glioma cells depend on exogenous cysteine/cystine, and dietary restriction extends survival in a mouse model, though tumors can later compensate by synthesizing glutathione.

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

This study characterizes an adaptive mutant of Lassa virus glycoprotein complex that confers resistance to fusion inhibitors and alters viral fusion properties.

This paper develops a microengineered lung organ chip model to study SARS-CoV-2-induced lung injury and immune responses, revealing distinct cellular responses and the role of immune cells in inflammation.

This paper uses UAV-captured multispectral images to predict sugarcane canopy nitrogen content and irrigation levels using PLS, BPNN, ELM, and SVM models.

The paper shows PRMT1 maintains neural stemness by coordinating ribosomes and proteasomes through arginine methylation, preventing degradation and supporting protein homeostasis in cancer and neural stem cells.

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

This paper designs a radial multi-offset detection pattern for in vivo phase contrast imaging of human retinal ganglion cells, achieving improved contrast and robustness compared to previous methods.

This paper improves strip-based image registration for eye-tracking in ophthalmic imaging to enhance motion accuracy and reduce image distortions.

This paper introduces 2bRAD-M, a low-cost metagenome-sequencing method that enables species-level microbial profiling of low-biomass and degraded samples with high accuracy.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

This paper introduces a dual-stage deep-learning network to enhance 3D fluorescence microscopy resolution and throughput, achieving faster imaging with improved contrast and subcellular detail.

This study evaluates deep learning denoising methods for improving particle tracking accuracy in noisy microscopy images, finding supervised learning generally outperforms unsupervised approaches.

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

This paper identifies a mammalian-unique eIF4E2-GSK3β pathway that prevents senescence and protects against hypoxia by maintaining p53 phosphorylation.

This study uses TRACE-seq to analyze single throat swabs, integrating SARS-CoV-2 genome, microbiome, antibiotic resistance, and host response data.

The paper presents an improved strategy for deep N-glycomics with optimized sample prep, isotope-based QC, new libraries, and algorithms, but the manuscript was withdrawn due to incomplete data.

The paper identifies a peroxidase inhibitor, 6D1, that enhances kanamycin activity against carbapenem-resistant bacteria.

This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.