N. Wang

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study maps the glycolytic targetome in cancer cells using TRAP, revealing 913 targets and 2,487 interactions for 10 glycolytic metabolites and their functional roles in cancer biology.

The paper uses molecular and morphological data to clarify species boundaries in Betula section Costatae, identifying a new species, Betula buggsii, within the group.

The paper investigates how microtissue geometry and cell-generated forces influence liver progenitor cell differentiation patterns in 3D by combining microfabrication, imaging, and mechanical modeling.

The paper tests hypotheses about genetic diversity patterns in Betula albosinensis, finding support for the central-marginal hypothesis and the role of multiple glacial refugia.

A cocktail of neutralizing antibodies targeting SARS-CoV-2 spike protein's NTD and RBD, when used as immunogens in rabbits, elicited strong protective immune responses.

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

This paper develops dual orthosteric-allosteric inhibitors of PfHT1 that selectively target malaria parasites over human cells, showing potent activity against multidrug-resistant strains.

This study resolves the phylogeny and polyploid parentage of birch trees using genome-wide sequence data, revealing two subgenera and complex reticulate origins of polyploid taxa.

The paper shows red-light promotes mutualism between begomovirus and whitefly by stabilizing βC1, which inhibits plant defenses through interference with PIFs and MYC2 transcriptional activity.

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

This paper shows how Begomovirus uses a phosphatase to suppress plant immunity, enhancing virus transmission by herbivore vectors.

This study shows that in FXN-depleted hearts, the integrated stress response (ISR) predominates over mTORC1 activation, despite reduced energy production, suggesting a protective mechanism.

This study shows that loss of Aldob activates Akt, promoting hepatocellular carcinoma by destabilizing the Aldob/Akt/PP2A complex, and identifies SMAP as a potential therapeutic agent.

The paper uses molecular markers and ecological niche models to study introgression between Betula tianshanica and Betula microphylla, finding bidirectional gene flow with implications for conservation.

This study designs and characterizes prefusion-stabilized SARS-CoV-2 spike variants to improve protein yield and stability for vaccine and diagnostic development.

This paper develops an efficient gene excision system in maize using inducible recombinases to improve transformation and regeneration of fertile plants.

The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

The paper uses proteomics to study citrus vascular responses to HLB, finding increased peroxidases and serine proteases during infection.

The paper determines the cryo-EM structure of the 2019-nCoV Spike protein in the prefusion conformation and shows higher ACE2 binding affinity compared to SARS-CoV.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

This study identifies four clinically used drugs with high binding capacity to SARS-CoV main protease, a potential target for treating 2019-nCoV infection.

The paper introduces an efficient long fragment editing technique for scarless genome engineering in E. coli, enabling large-scale DNA insertion and deletion with high success rates.

This study develops a reversed paired-gRNA plasmid cloning strategy to eliminate plasmid instability caused by direct repeats, achieving efficient genome editing in E. coli.

The paper identifies CbuSPL9 and its interacting protein CbuHMGA in Catalpa bungei, showing they form a heterodimer and may regulate flowering development, not transition.

This study identifies ALBA proteins in Arabidopsis as redundant regulators of growth and flowering, with minimal impact on transcriptome composition.

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.