N. Zhang

This study shows O-GlcNAc modification of MTA1 enhances its chromatin binding and transcriptional activity, aiding breast cancer cells in adapting to genotoxic stress.

This study determines the structure of the p75NTR-DD/TRADD-DD complex and shows TRADD recruitment regulates NF-κB signaling and cell survival in cerebellar granule neurons.

This study uses deep learning to predict cell sizes from laser mode imaging of single-cell lasers, demonstrating sub-wavelength accuracy in both synthetic and biological cell models.

The paper describes a new fungal genus and species from root-associated environments, proposes a new family based on phylogenetic and phenotypic data, and highlights limitations of sequence-only analyses.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This study uses three-color single-molecule imaging to track dynein's conformational dynamics during motility, revealing variable stepping between domains and a large number of conformational states.

This study shows that human ILC2 cells can be activated by TLR4 signaling through LPS, leading to cytokine production and B cell activation, distinct from classical IL-33 activation.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper investigates cross-reactivity between mugwort and house dust mite allergens, finding that mugwort tropomyosin induces a non-Th2 response in allergic rhinitis patients.

This paper shows anti-asprosin monoclonal antibodies reduce appetite, body weight, and blood glucose in metabolic syndrome mouse models.

The study examines how different low-temperature conditions affect microbial communities in an Anearobic-Anoxic-Oxic wastewater treatment process on the plateau, finding temperature impacts on specific bacterial abundances.

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

The paper identifies lysine isobutyrylation as a new histone modification mark and shows its role in epigenetic regulation and cellular physiology.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

This study maps QTL for leaf angle in maize using an F3:4 RIL population and identifies 24 candidate genes in two QTL regions.

This study examines genetic sources of variation and variability in Drosophila grooming behavior, finding that genetic differences lead to distinct phenotypes but not increased individual variability.

This study shows PKD1 phosphorylates CBX8, disrupting PRC1 complex binding and promoting cell senescence by derepressing p16.

This paper develops and validates prime editing vectors for plants, enabling large insertions and fluorescent tagging in dicots and monocots.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

B cells integrate innate TLR and adaptive CD40 signals to induce BATF3 transcription factor for production of IL-27, which together with INFg optimizes antibody responses.

This study identifies SETD2 as a factor that interacts with hnRNP L to regulate alternative splicing by linking transcription and splicing through its SHI domain.

This study shows that the disordered N-terminal region of SETD2 regulates its proteasome-mediated decay, affecting H3K36me3 deposition and transcriptional fidelity.

The paper identifies EB1 as an interacting partner of PTPN22 and shows that this interaction regulates T cell receptor signaling by modulating EB1 phosphorylation and downstream signaling molecules.

This study identifies two bacterial lipases with broad-spectrum antiviral activity against multiple enveloped viruses, including SARS-CoV-2, by disrupting viral envelopes.

The paper introduces 2D-HELS-AA MS Seq to directly sequence tRNA, revealing different isoforms and dynamic base modifications.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

The paper identifies metabolic subtypes of colorectal cancer using metabolomics and finds correlations between these subtypes and clinical outcomes.

This study profiles the 2-hydroxyisobutyrylome in common wheat, identifying Khib modification sites and their roles in metabolic pathways and enzyme regulation.

This study shows SlWak1 promotes apoplastic immune responses to Pseudomonas syringae in a Fls2- and Fls3-dependent manner, acting in a complex with these receptors during PTI.