T. Chen

This study identifies PbE3-2, a protist effector that degrades RD21A to suppress plant immunity, contributing to clubroot disease.

This study evaluates an intranasal influenza-based vaccine against SARS-CoV-2 variants, showing it reduces inflammatory response and tissue damage through local immunity.

This study shows RGA1 improves pollen tube growth under low-light by enhancing sugar and energy metabolism in rice pistils.

This study identifies CURLY LEAF (CLF) as a key regulator of apoplast water status in Arabidopsis by modulating ABA signaling and stomatal closure.

The paper develops human monoclonal antibodies targeting the ACE2 receptor to block infection by SARS-CoV-2 and related sarbecoviruses, showing broad efficacy against variants and no adverse effects on ACE2 function.

This study shows that PV001-DV, an attenuated Dengue virus, induces oncolytic cell death and activates anti-tumor immunity in melanoma and breast cancer cells.

The paper identifies a collagen glucosyltransferase in Acanthamoeba Polyphaga Mimivirus through genomic and structural analysis, revealing its unique enzymatic activity and substrate specificity.

This study analyzes the temporal transcriptome changes in porcine macrophages infected with different ASFV strains to understand viral pathogenicity and host response dynamics.

This study uses single-particle cryo-EM to determine the structure of a native α-carboxysome from a marine cyanobacterium, revealing its shell architecture and internal enzyme organization.

The paper identifies conserved neutralizing epitopes on the N-terminal domain of SARS-CoV-2 spike proteins using NTD-specific probes and characterizes antibodies that neutralize multiple variants.

This paper shows that SARS-CoV-2 Spike protein inhibits CFTR signaling in airway epithelia, leading to inflammation similar to cystic fibrosis.

This paper describes a platform for supported lipid bilayers that can be electrically controlled and optically probed to study membrane polarization dynamics.

The paper uses mass spectrometry to determine the absolute stoichiometry of native and recombinant carboxysomes, revealing structural variability and assembly principles.

This paper develops a full-length, membrane-bound SARS-CoV-2 spike model with post-translational modifications, revealing how glycosylation and palmitoylation enhance its conformational dynamics and interaction with host cell receptors.

This study shows that oral administration of BefA from E. coli reduces blood glucose and improves beta cell function in both T1DM and T2DM mice.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.

Sorbitol promotes early flower bud differentiation in loquat by upregulating the MADS-box transcription factor EjCAL through the ERF12 regulatory pathway.

This study investigates ovule abortion in Paeonia ludlowii, identifying types, developmental stages, and morphological differences between aborted and fertile ovules.

This study shows cardiac medications like ouabain and digitoxin inhibit ACE2 binding to SARS-CoV-2 Spike and block virus entry into human lung cells.

This study analyzes rabies virus variants from ferret badgers in China, identifying four lineages and assessing their pathogenicity and distribution.

This study shows that combining SHP2 and CXCR1/2 inhibitors enhances anti-tumor T cell responses in NSCLC by reducing immunosuppressive gMDSCs and promoting effector T cells.

The paper shows that morphogenesis in multi-layered tissues is self-organized by interfacial mechanical interactions that create compression gradients, leading to stratification or 2D morphogenesis depending on tissue fluidity.

This study identifies CX-5461 as a TOP2B inhibitor with selective activity in high-risk neuroblastoma but highlights safety concerns due to TOP2B off-target effects.

This paper integrates crop growth and radiative transfer models with deep learning to improve the estimation of crop traits from hyperspectral data.

This study shows that colonic epithelial cells adapt to EGFR-independent growth, leading to chromosomal instability and accelerated by prior injury, without introducing cancer driver mutations.

This paper develops a novel transgenic mouse model expressing EGFRvIII-CAR on T-cells to study CAR T-cell therapy in syngeneic glioblastoma models.

This study shows Rab25 coordinates cytokinetic bridge abscission and cortical actin density in zebrafish gastrula epithelium, affecting cell shape and tissue-scale forces during epiboly.

The paper identifies and characterizes a novel adipocyte population with active Wnt/β-catenin signaling that influences beige fat formation and glucose homeostasis in mice.

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

The paper establishes patient-derived orthotopic xenograft models and cell lines from pediatric high-grade glioma that replicate histopathology, molecular signatures, and drug response, providing a resource for research.