W. Chen

This study shows that the FER-CAR module regulates plasma membrane nano-organization and immune signaling through a feedback loop during RALF1 signaling.

The paper identifies the abfA cluster as a key genetic factor for arabinan utilization in gut microbiota, showing its therapeutic potential for constipation through improved gut motility and metabolite production.

This study isolates urease-producing bacteria from the cultivation environment of Gracilariopsis lemaneiformis and shows they enhance urea uptake and nitrogen assimilation by the macroalgae.

The paper uses computational simulations to study how cell mechanics regulate isotropic collagen matrix modeling at large spatial scales, revealing key cellular mechanisms involved.

The paper presents a chromosome-level genome assembly of T. grandis and identifies genes responsible for gymnosperm-specific sciadonic acid biosynthesis.

MCATS detects cell-generated forces using CRISPR-Cas12a, showing drug effects on platelet forces and identifying platelet dysfunction after cardiopulmonary bypass.

The paper identifies an mRNA motif regulated by TGF-β1 that enhances translation of NEU3, and shows that inhibiting the binding protein DDX3 reduces pulmonary fibrosis in mice.

This study uses single-cell RNA-seq to analyze immune cells in ME/CFS patients at baseline and after exercise, identifying dysregulated monocytes and platelet transcriptomes.

This study develops a novel medium for iPSC-derived cardiomyocytes using differential evolution to enhance maturation, validated through multiomic analysis.

This study identifies horizontally transferred genes (HTGs) in aphids and whiteflies as potential RNAi targets for pest control, showing they can be silenced without harming beneficial insects.

This paper introduces a cryoFIB milling workflow for isolating objects of interest from large tissue samples, resulting in thin lamellae suitable for cryo-electron tomography.

This study examines changes in lung sialidase expression in male and female mice after bleomycin aspiration, finding differential expression patterns and fibrosis association with NEU3.

This study identifies antibodies effective against Omicron by analyzing epitope changes and binding patterns, showing their ability to neutralize the virus through a conserved mechanism.

The paper identifies RALF33-FER as an early signaling module between wounding and root regeneration, interacting with TPL/TPRs to regulate regeneration-related genes.

This study uses synthetic fibrous hydrogels to investigate cell-matrix mechanical interactions and their impact on cellular behavior.

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

This study shows Bengalese finches can discriminate between conspecific frontal and lateral head orientations and form a learning set during training, but without a clear categorization boundary.

The paper improves TurboID labeling in C. elegans by depleting endogenous biotinylated carboxylases to enhance interactome analysis.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This study shows that prior influenza infection increases resistance to secondary bacterial infection by altering the lung immune environment.

This study shows that the RelA TAD increases NFκB-DNA binding affinity but reduces specificity for κB sequences by enhancing non-specific DNA binding.

The paper identifies two new subunits, AmoY and AmoZ, in the ammonia monooxygenase of ammonia oxidizing archaea, revealing structural and functional complexity.

The paper uses single-cell transcriptomics to identify immune cell states and cytokine interactions linked to poor neurological outcomes after cardiac arrest.

This study shows that FER-mediated phosphorylation of GRP7 promotes phase separation, enhancing Arabidopsis temperature resilience by forming stress granules that inhibit translation during temperature shifts.

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

This study shows that NEU3 sialidase is necessary and sufficient for pulmonary fibrosis in mice, with its enzymatic activity driving inflammation and fibrosis.