W. Chen

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

This study isolates and characterizes two mesenchymal stem cell lines from a neonatal common hippo, showing their fibroblastoid morphology, normal karyotype, and stemness markers, with distinct differentiation potentials.

This study extracts and purifies β-2,7,11-cembratriene-4,6-diol from tobacco leaves and demonstrates its antiviral activity against TMV through in vivo and molecular assays.

This study shows MAL suppresses OSCC by maintaining epithelial differentiation, with MAL and its co-functional genes as potential biomarkers for prevention and therapy.

This study integrates DNA methylome and transcriptome data from Salmonella Typhimurium under different conditions, finding that DNA methylation is largely static and only rarely correlates with gene expression changes.

This study uses top-down proteomics to identify 23,319 proteoforms in colorectal cancer cell lines and finds significant proteoform-level differences between metastatic and non-metastatic cells.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

The paper identifies oxalic acid as a ligand for the brown planthopper's gustatory receptor Gr23a, showing it inhibits feeding and is sensed by the receptor.

This study uses an ensemble of explainable AI models to uncover expression signatures of synergistic drug response in AML, revealing a hematopoietic differentiation signature as a key factor.

This study shows SARS-CoV-2 indirectly causes BBB injury and neuroinflammation through systemic inflammation, not direct viral infection, using a linked alveolus-BBB organ chip platform.

This study analyzes the reassortment network of Influenza A Virus using genome-wide data to identify reassortment events and their evolutionary implications.

This study acquires and analyzes the macromolecular MR spectrum in healthy adults across ages 20-69, finding no significant age or sex-related changes in macromolecule signals.

This study identifies a KCNQ1 mutation causing neonatal diabetes by impairing β-cell function and survival through electrophysiological and transcriptomic analyses.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study uses single-nucleus RNA-seq and spatial transcriptomics to identify lineage-specific regulatory changes and candidate therapeutic targets in hypertrophy cardiomyopathy.

This study identifies BcPTP1 as a phytotoxic effector secreted by Botrytis cinerea during late infection, which induces cell death and promotes lesion spreading.

The paper shows that lipid droplets form early after viral infection, support interferon production, and reduce viral replication.

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

This study demonstrates that stem cell-derived secretome reduces intraocular pressure and protects retinal ganglion cells in glaucoma models through COX2-PGE2 pathway activation and extracellular matrix remodeling.

This study shows that BSCL2 deficiency in the heart causes heart failure through excessive lipid catabolism, reduced energy reserves, and ATP levels, which can be mitigated by inhibiting fatty acid oxidation or high-fat diet.

This study identifies two molecular subtypes of gastric cancer using multi-omics data and clustering algorithms, showing distinct survival outcomes and therapeutic responses.

The paper identifies distinct transcriptional programs driving the expansion of stromal progenitors in mesenteric lymph nodes, revealing Irf3's role in FRC differentiation and microbiota-independent epigenomic signatures.

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

The paper develops a high-throughput yeast assay to profile permeability of all 13 Arabidopsis PIP aquaporins to various substrates and links results to their biological roles and structural features.

This study shows KSHV infection of MSCs drives MEndT to generate hybrid M/E state cells, which are tumorigenic and recapitulate KS features, with vFLIP as a key regulator.

The paper identifies SFRP2+ fibroblast progenitors as the source of myofibroblasts in systemic sclerosis skin using single-cell RNA sequencing.

This study shows KSHV resolves the bivalent chromatin of PROX1 to activate its expression, promoting MEndT and tumorigenic features in MSCs.

This study establishes and characterizes fibroblast cultures from a female common hippopotamus, confirming their origin and viability for genetic preservation.

This study identifies 12 serum metabolites associated with esophageal squamous cell carcinoma and highlights pipecolic acid as a predictive biomarker for tumorigenesis.

This paper presents a hardware-software solution for co-registering photoacoustic tomography and MRI images in vivo, demonstrating hybrid-contrast imaging of tumor microenvironments.