X. Chen

The paper identifies Ms4a3 as a marker for tracking monocyte-derived cells and quantifies their contribution to tissue-resident macrophages during homeostasis and inflammation.

This study shows AP-1 activity is essential for chromatin opening during T cell activation and links AP-1 to immune disease risk loci.

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

The paper reports the crystal structure and cryo-EM reconstruction of a constitutively active Drosophila Orai mutant, revealing the molecular mechanism of channel activation and Ca2+ permeation.

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

This study identifies novel Kir6 channel inhibitors using computational methods, validated by experimental analysis, with potential for treating Cantu syndrome.

This study shows chronic stress increases oxytocin levels, which promotes melanoma metastasis via β-arrestin 2-dependent pathways, suggesting OXT as a therapeutic target.

This study shows that fast-cycling granulocyte-macrophage progenitors are more likely to transform into leukemia when expressing the MLL-AF9 oncogene.

The paper analyzes the hypothalamic transcriptome of Muscovy ducks across reproductive stages to identify gene expression changes and pathways involved in broodiness.

The paper assesses RNA folding specificity in mRNA and noncoding RNA, finding that specific folding is more evolutionarily adaptive and functionally significant.

This study uses RNA-seq to analyze gene expression in Pseudomonas syringae pv. actinidiae during early kiwifruit infection, identifying three distinct phases of gene expression.

This study shows that microglia regulate neuroglia remodeling in ocular injuries, and their depletion leads to increased inflammation and retinal damage.

The paper examines the relationship between ecological stoichiometry and plant community diversity in arid ecosystems of the Tarim River, finding significant correlations between nutrient content and diversity indices.

This study shows Oct1/Pou2f1 is essential for gut regeneration but has opposing roles in colon cancer depending on the tumor model.

This study identifies and analyzes DNA methyltransferase genes in cotton, showing their functional diversity and stress-specific expression patterns.

This study identifies circZKSCAN1 as a negative regulator of cancer stem cells in hepatocellular carcinoma, revealing its mechanism through interaction with FMRP and CCAR1-Wnt signaling.

This study examines how different fruit tree shade intensities affect wheat growth, yield, and quality in intercropping systems, finding that shade reduces yield components but increases protein content and dough properties.

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

This study shows GFI1 acts as a tumor suppressor in colorectal cancer by reducing its expression in advanced stages and inhibiting tumor growth in models.

This study develops a fluorescent probe to measure glutathione concentrations in the nucleus and cytosol, finding no significant concentration gradient between them.

This study compares the microbiome of Schlechtendalia chinensis aphids on two host plants, finding distinct bacterial communities associated with each host.

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

This paper investigates the sequence diversity and evolutionary patterns of the fhuA gene in Salmonella and Escherichia, revealing unique clustering and mutation patterns that suggest gene recombination and selection pressure.

This study analyzes 255 chronic osteomyelitis patients in northern China, finding higher prevalence in males aged 41-50, common infection sites, and better outcomes with two-stage debridement and antibiotic-loaded PMMA beads.

The paper identifies YrlA RNAs as tRNA mimics in bacteria, showing structural similarities to tRNAs but with key differences.

The paper shows that miR1510 in Phaseoleae species is primarily a 22 nt isoform due to monouridylation, and demonstrates how post-processing modifications can optimize miRNA function.

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.

This study identifies LINC00844 as an androgen-regulated lncRNA that suppresses prostate cancer migration and invasion by modulating AR chromatin binding and NDRG1 expression.

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.