X. Fu

This study constructs and analyzes Stroke Symptom-Herb Networks (SSHNs) from historical TCM prescriptions to reveal their dynamic structure and evolutionary trends over 1700 years.

This study identifies SYVN1 as an E3 ubiquitin ligase that promotes GSDMD-mediated pyroptosis by ubiquitinating GSDMD at specific residues.

This study creates a novel murine model of severe G6PD deficiency by introducing a human mutation, revealing metabolic alterations and hemolytic sequelae similar to humans.

This study shows that viral proteins interact combinatorially, leading to new biological functions beyond their individual roles during infection.

This study identifies additional ORFs in geminiviral genomes that encode small proteins with specific subcellular localizations and virulence functions.

This study identifies how coronavirus Nsp5 protein inhibits pyroptosis by cleaving GSDMD, preventing pore formation and viral replication inhibition.

The paper studies bacterial group migration and finds that spatially modulated individual behaviors enable coherent collective movement without complex computation.

The paper determines the structure of the HIV Gag six-helix bundle using cryoET and identifies small molecules stabilizing the immature lattice.

The paper compares loop extrusion and diffusion capture models of SMC complex function in mitotic chromosome formation using simulations and experimental data.

This study investigates the role of Ecm2 in yeast splicing, showing it modulates catalytic steps and facilitates splice site usage.

This study characterizes the microbial composition and environmental factors in hotel rooms across continents, finding associations between fungal and bacterial diversity, quantity, and environmental characteristics.

The paper visualizes a novel single-shelled icosahedral intermediate of mammalian orthoreovirus using cryo-electron tomography, revealing structural insights into viral assembly.

The paper uses serial cryoFIB/SEM to show cytoarchitectural disruptions in Leigh syndrome patient fibroblasts due to a USMG5 mutation.

The paper shows that inactivating the TN/TX microRNA-degrading enzyme in mice causes adiposity similar to Tsn deletion, but cell-specific deletion does not replicate this effect.

This study restores vision in blind mice by reprogramming Muller glia to retinal neurons, demonstrating a potential treatment for end-stage retinal degeneration.

This study shows that miR-203 suppresses pancreatic cancer cell proliferation, invasion, and migration by down-regulating FGF2 expression.

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

The paper demonstrates that antibiotic-resistant cells can be inhibited by exploiting fitness trade-offs using norvaline to target genetic mutations in leucyl-tRNA synthetase in tavaborole-resistant E. coli.

The study links indoor microbial communities in university dormitories to asthma symptoms, finding specific taxa from different ecological niches are associated with increased or protective effects on asthma.

This study compares microbial composition in floor and air dust from university dormitories, showing significant differences that affect downstream microbiome analysis.

This study identifies miR476a/RFL as a regulator of adventitious root formation in poplar through mitochondrial homeostasis and auxin pathway modulation.

This study identifies a pathway connecting plasma membrane and chloroplasts that pathogens exploit to suppress salicylic acid-dependent defenses.

This study challenges two established dogmas about bacterial cell growth and reveals a new linear relation between cell mass and division count across a wide range of growth rates in E. coli.

This study identifies GATA3 and AP1-driven enhancer reprogramming as a mechanism promoting phenotypic plasticity and endocrine resistance in breast cancer.

The paper uses living-cell protein crosslinking to show the ε-subunit of ATP synthase exists in an equilibrium of inserted and non-inserted states, with inserted state enhancing ATP synthesis under stress.

The paper identifies novel haplotypes and evolutionary pathways of AVR-Pik alleles in Magnaporthe oryzae using DNA sequence analysis and field-based avirulence testing.

The paper studies how clonal Escherichia coli cells maintain collective migration despite individual differences in chemotactic ability through spontaneous spatial sorting within the moving band.

The paper shows PGC-1α and Bcl-2 work together to reduce ROS and delay cell cycle progression in U251 cells after serum depletion.