X. Han

This study uses single-cell RNA sequencing to identify five MSC subpopulations, revealing distinct developmental trajectories and functional roles in self-renewal and immunoregulation.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.

The paper investigates the role of the intrinsically disordered region (IDR) in coronins, showing it fine-tunes oligomerization and actin polymerization through evolutionary conserved patterns.

This paper develops self-powered artificial cell colonies that mimic muscle behavior through actin polymerization and depolymerization, showing reversible deformation and collective contraction.

This study investigates how orthoformimycin inhibits translation elongation by displacing the A-site tRNA and blocking peptide bond formation using X-ray crystallography and kinetic analysis.

This study investigates how cancer affects insulin signaling and glucose transport in different muscle types, finding muscle-specific impairments in insulin response and signaling pathways.

The paper investigates the role of parthenogenetic Asian longhorned ticks in spreading SFTSV, finding they contribute to rapid spread and long-range movement.

The paper examines the 13,500-year sedimentary record of Lake Cadagno to study microbial activity and geochemical changes, revealing redox shifts and a deep oxidizing groundwater source impacting organic matter remineralization.

This study shows that soil inoculum origin and amount affect microbiome and plant community development in degraded grasslands over three years.

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

This study compares proteomic profiles of vancomycin-intermediate resistant S. aureus strains to identify differentially expressed proteins associated with vancomycin resistance.

This study develops a high-throughput method to produce functional prototissues that generate nitric oxide, inducing vasodilation in rat blood vessels.

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

The paper identifies MK-derived immune-stimulating cells (MDICs) that enhance host defense against bacterial infections by interacting with myeloid cells and producing cytokines.

This paper introduces a multiview super-resolution microscopy approach that enhances confocal microscopy resolution and reduces phototoxicity across multiple scales.

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

This study identifies PRMT1-mediated methylation of DUSP4 as a regulator of p38 MAPK activity, influencing megakaryocyte differentiation and thrombocytopenia in myelodysplastic syndromes.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study analyzes fungal communities in Chinese Marselan wine fermentation across regions, finding that environmental factors significantly influence fungal composition and fermentation performance.

This paper introduces a polymer gel matched to water's refractive index, enabling high-resolution imaging of living cells and organisms in thick layers.

This study identifies a linear epitope on SARS-CoV-2 S-RBD recognized by a potent neutralizing antibody and shows its potential for vaccine design.

This paper introduces a rapid screening system to identify potent neutralizing antibodies against SARS-CoV-2 and demonstrates its effectiveness in discovering high-potency antibodies.