X. Li

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

This study shows that SETD2 deficiency in mice worsens colonic inflammation and tumorigenesis by increasing oxidative stress and impairing epithelial barrier function.

This study identifies TMEM-120/TMEM120A as a conserved protein that promotes fat storage by enhancing triacylglycerol synthesis and lipid droplet expansion in C. elegans and mammalian cells.

This study identifies DAB2IP as a tumor suppressor in colon cancer that inhibits p53 degradation by competing with GRP75 for binding, thereby enhancing p53 stability and suppressing tumor growth.

This paper shows that SARS-CoV-2 triggers mast cell degranulation, leading to alveolar epithelial inflammation and lung injury, and that MC stabilizers can reduce these effects.

The paper reports the structure of ASFV g5Rp and its complex with InsP6, revealing how InsP6 inhibits mRNA decapping by competing with RNA binding sites.

This study identifies CXCL6 as a pro-fibrotic factor in IPF, showing it reduces cAMP, increases collagen and -SMA, and correlates with poor patient survival.

This paper shows that nanoscale surface topography reduces focal adhesions and cell stiffness by enhancing integrin endocytosis, mimicking the effects of soft substrates on rigid materials.

This study shows that RANKL from bone marrow adipocytes regulates trabecular osteoclast formation and bone loss in mice, with implications for therapeutic targeting of bone marrow adiposity.

This study shows that inhibiting AHR signaling enhances terminal differentiation of human erythrocytes by promoting F-actin remodeling and cytoskeleton maturation.

This study uses deep metagenomics to explore microbial communities in Challenger Deep sediment, revealing new MAGs, metabolic functions, and virus-host interactions in hadal zone ecosystems.

This paper introduces CHAMP, a computational microscopy method for high-throughput, label-free histological imaging, and demonstrates its ability to generate virtually stained images through unsupervised learning.

This paper develops a mathematical model of intratumor heterogeneity in breast cancer that quantitatively matches experimental data and predicts therapeutic strategies to improve treatment efficacy.

This study identifies genomic changes and novel toxins in Liberibacter pathogens through comparative phylogenomic analysis, linking prophage loci and gene gains/losses to pathogenicity.

This paper introduces a method to observe 3D subcellular dynamics in vivo at high resolution and speed, demonstrating its application in various biological systems.

This paper applies RCAN to enhance fluorescence microscopy image volumes, achieving denoising and resolution improvements across multiple microscopy techniques.

The paper introduces new anti-O-GlcNAc antibodies for efficient enrichment of native O-GlcNAc modified peptides, identifying over 1,300 unique peptides with reduced sample and time requirements.

This study identifies SIRT1's role in regulating sphingolipid metabolism and neural differentiation in mESCs via c-Myc and SMPDL3B, suggesting therapeutic potential for neurological diseases.

The paper profiles longitudinal immune responses in mild COVID-19 patients to identify recovery and persistence signatures.

This study compares bacterial communities in sediment and water of thermokarst lakes, finding distinct differences in diversity and community structure, with rare taxa showing stronger environmental structuring.

The paper examines sex-specific metabolic differences in offspring of obese mothers, showing females have better metabolic outcomes due to more efficient transcriptional and posttranscriptional reprogramming.

This study shows TIR signaling enhances the interaction between EDS1/PAD4 and ADR1-L1 and promotes ADR1-L1 oligomerization, crucial for immune activation and cell death.

The paper compares the antigenicity of neuraminidase (NA) from circulating influenza A viruses to vaccine strains, finding antigenic similarity and highlighting C-terminal substitutions affecting H3N2 NA reactivity.

This study identifies SiAUX1 as critical for lateral root development in Setaria italica, revealing its role in cell volume distribution and vascular strand formation through mutant analysis and RNAseq.

This paper develops a Cas13a-based assay for detecting Neisseria gonorrhoeae and identifying azithromycin resistance mutations, showing high sensitivity and concordance with existing methods.

This study evaluates a modified B.1.351 spike trimer vaccine candidate, showing it induces broad neutralization against multiple SARS-CoV-2 variants in mice.

This study introduces a contraction-reaction-diffusion model that generates circular patterns in embryogenesis by coupling mechanobiological factors with traditional reaction-diffusion equations.

This study shows that Smad4 loss promotes lung cancer metastasis by upregulating PAK3 through miRNA regulation, suggesting Smad4 LOF as a prognostic marker and therapeutic target.

This study evaluates the in vitro efficacy of gentamicin alone and in combination with three antibiotics against multidrug-resistant Neisseria gonorrhoeae, finding synergistic effects in some combinations.