X. Liu

The paper establishes the near-atomic molecular architecture of the cytoplasmic face of the human nuclear pore complex using interdisciplinary methods.

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

This study identifies ISCA2 as a target for inhibiting HIF-1/2 and inducing ferroptosis in clear cell renal carcinoma, showing efficacy in xenograft models.

This study evaluates an intranasal parainfluenza virus-vectored SARS-CoV-2 vaccine in macaques, showing it induces mucosal and systemic immunity and protects against viral challenge.

The paper reanalyzes fliL mutant studies and finds that retention of the N-terminal region, including the transmembrane helix, negatively modulates bacterial motor output.

The paper catalogs 19,251 non-human reference genomes from Qinghai-Tibetan Plateau animals, revealing new insights into mammalian gut microbiome diversity and host-microbe interactions.

The paper compares exercise and antioxidant intervention in type 2 diabetic rats, showing both improve blood glucose via hepatic AMPK activation and redox balance, with exercise promoting moderate ROS for AMPK activation.

This study shows intermittent fasting improves cognitive function in Alzheimer's mice by reducing Aβ and neuroinflammation, and through gut microbiota and metabolite changes.

This study demonstrates that Notch ligand dimers mediate cis-inhibition of Notch receptor activity, introducing a new model of Notch signaling that distinguishes between ligand monomer-driven transactivation and dimer-mediated cis-inhibition.

This study identifies three molecular subtypes of synovial sarcoma through multi-omics analysis, linking BAF complex alterations to tumor evolution and clinical outcomes.

This paper develops a framework for generating device-specific optimal PSFs for 3D super-resolution imaging using deformable mirrors, demonstrating superior performance over conventional PSFs.

This study shows that HPV E6 reduces mitochondrial antioxidant capacity and therapy resistance in oropharyngeal cancer by suppressing the PGC-1α/ERRα pathway.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study identifies the N-terminal domain (NTD) of p53 as the major binding site for Cyclophilin D, revealing dynamic electrostatic interactions and a minimal binding region for mPTP regulation.

This paper develops a deep learning-based preprocessing tool to analyze urothelial cell clusters in urine cytology, identifying key markers of atypia that could improve machine learning applications in bladder cancer detection.

This study compares the transcriptomes of Geobacter metallireducens during DIET with different electron-accepting partners, showing varied gene expression and requirements for DIET.

This study develops NanoSTING, an intranasal nanoparticle STING agonist, showing broad protection against respiratory viruses and variants in animal models.

This paper reports the crystal structure of Rubella virus protease and demonstrates its protease and deubiquitylation activities, providing insights for antiviral drug development.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This paper reports a synthetic nanobody, C5G2, that neutralizes SARS-CoV-2 and Omicron variants with high potency through a unique binding mechanism.

This paper identifies an Acidobacterium that produces diverse brGDGTs and shows temperature primarily controls C5-methylation while cyclization is influenced by multiple factors.

This paper introduces a new histologic grading system for murine knee osteoarthritis that scores the entire joint, showing high reproducibility and sensitivity for detecting OA progression.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

This study shows that modulating STAT1 signaling in chemotherapy-primed breast cancer enhances anti-PD-1 immunotherapy efficacy by altering myeloid cell dynamics.

This study compares the genomes of 74 Lactobacillus acidophilus isolates from different niches to explore genomic diversity and ecological adaptation.

This study shows that both tree species and genetic diversity increase productivity through functional diversity and trophic feedbacks, with genetic diversity effects varying between monocultures and mixtures.

This study identifies how CD11b agonists trigger STING-interferon signaling in tumor-associated macrophages to enhance anti-tumor immunity in mouse models and human cancer patients.