X. Wang

The paper examines how TP53 mutations affect antitumor immunity differently across cancer types, finding varying correlations with immune signatures and tumor mutation burden.

This study identifies ANP32A and ANP32B as essential for influenza A virus polymerase activity, showing species-specific roles and mutations affecting viral replication.

This paper elucidates the compartmentalized biosynthetic pathway of mycophenolic acid, revealing subcellular localization of enzymes and cooperation with β-oxidation machinery.

This study shows that SS-31 reverses mitochondrial fragmentation and increases ROS in DCMA fibroblasts, suggesting it as a potential therapy for this mitochondrial cardiomyopathy.

The paper investigates the mechanisms controlling E2F8 dynamics during the cell cycle using cell-free systems, revealing phosphorylation, ubiquitination, and transcriptional regulation.

This paper identifies the role of TYLCV V2 protein in facilitating the nuclear export of V1 protein and viral systemic infection through host exportin and V1-V2 interaction.

The paper develops a method to estimate immune cell content in tumors using scRNA-seq reference data, showing improved performance over existing methods in distinguishing immune subtypes.

This study shows glycogen metabolism via the oxidative pentose phosphate pathway (OPPP) initiates photosynthesis in cyanobacteria by modulating NADPH levels during dark-light transitions.

The paper shows how regional climate differences affect salmon lice population dynamics, stage structure, and management strategies.

This study develops PSMA-targeted nanobubbles for real-time ultrasound imaging of prostate cancer in mice, showing improved tumor detection and retention.

The paper develops improved CRISPR/Cas9 methods for genome editing in Culex quinquefasciatus, achieving higher embryo survival and germline mutagenesis rates.

The paper designs a DNA nanostructure that recognizes and inhibits dengue virus through precise spatial arrangement of aptamers, enabling sensitive and rapid sensing and inhibition.

This study identifies IL17 and senescence as regulators of the foreign body response, showing their roles in fibrosis and potential as therapeutic targets.

This study quantitatively investigates how RNA polymerases interact with condensin loop extrusion, showing RNAPs act as steric barriers that impede the process, particularly in highly transcribed regions.

This study identifies ANP32A and ANP32B as essential host factors that facilitate HIV-1 unspliced RNA export via the Rev-CRM1 pathway.

This study identifies G3BP1 as a host factor essential for norovirus infection and reveals its role in VPg-dependent translation initiation.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

This study investigates the selectivity of 4-aminoquinolines for the alpha2A-adrenoceptor using docking, molecular dynamics, and mutagenesis to identify binding sites and affinity determinants.

This study uses transposon-insertion sequencing to identify genes required for EHEC growth in vitro and in vivo, revealing new factors critical for intestinal colonization.

This study analyzes genome-wide divergence patterns in two incipient shorebird species with gene flow, finding distinct genomic regions associated with reproductive isolation and adaptation.

This study shows that SCFAs from gut microbiota stimulate GLP-1 secretion in chickens, which suppresses hepatic lipogenesis.

PDE1 inhibition enhances proteasomal degradation of misfolded proteins via PKA and PKG activation, reducing cardiac proteinopathy and HFpEF in CryABR120G mice.

This study shows that HPV16 regulates SAMHD1 expression in oral keratinocytes, and SAMHD1 deletion enhances viral replication and cell proliferation in HPV16-infected cells.

This study identifies E-cadherin's role in suppressing sarcoma growth through both signaling (inhibiting p-CREB and TBX2) and mechanical (enhancing cell-cell adhesion) mechanisms.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

This study shows that fast-cycling granulocyte-macrophage progenitors are more likely to transform into leukemia when expressing the MLL-AF9 oncogene.

This paper identifies MraW as a DNA methylase in E. coli O157:H7, showing its role in motility, colonization, and virulence through genome-wide methylation and regulation of flagellar genes.

The paper evaluates pKa prediction methods using a dataset of kinase inhibitor-like fragments measured by UV absorbance and NMR.

This paper shows that SIRT1 deacetylates WRN to regulate its interaction with E1-E2 replicating DNA, controlling replication fidelity and quantity in HPV16.

This paper identifies and characterizes a novel paraoxonase-like enzyme in Trichoderma atroviride strain T23 that degrades DDVP and related organophosphate-oxons, showing high activity and specific kinetic parameters.