X. Wei

The paper reports the Cryo-EM structure of S. pombe NatC complex and identifies IP6 as a stabilizer, revealing substrate specificity overlaps with NatE.

This study uses scRNA-seq to analyze skeletal muscle response to denervation, finding selective activation of muscle-resident glial cells and fibroblasts, and their role in NMJ repair and fibrosis.

This study identifies 412 foamy viruses from 6 lineages in amphibians, revealing co-evolutionary patterns and cross-species transmission across Paleozoic to Cenozoic eras.

This study identifies exosomal miR-224's role in maintaining hemolymph microbiota homeostasis during bacterial infection in mud crabs by modulating immune signaling pathways.

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

This study examines how energy substances, reactive oxygen species, enzyme activities, and endogenous hormones influence somatic embryogenesis and abnormal callus formation in Ormosia henryi Prain.

The paper determines cryo-EM structures of MlaFEDB and reveals its phospholipid transport mechanism, identifying functional residues and providing insights for antimicrobial drug development.

This study identifies the metabolic pathways regulated by c-GMP in tomato seedlings under salt stress, showing its role in enhancing salt tolerance through changes in gene expression and metabolic profiles.

The paper develops a two-target qPCR assay to predict human-to-microbe ratios in samples, enabling better planning of shotgun sequencing experiments.

This study shows that dyclonine inhibits TRPV3 channels in keratinocytes, rescuing cell death and reducing pruritus in a mouse model.

This study analyzes 8,839 C. difficile genomes to reveal recombination-driven evolution of toxins A and B, develops a subtyping method, and creates a database for therapeutic and research use.

This study compares the DNBSEQ-G400 and Illumina MiSeq platforms for metabarcoding fungal communities, finding DNBSEQ-G400 to be more accurate, less biased, and cost-effective.

This study examines the effect of delayed processing on ovarian tissue for fertility preservation, finding that a 48-hour delay before cryopreservation does not negatively impact primordial follicle health.

This study identifies SF3B1 mutations causing anemia in MDS by inducing missplicing of MAP3K7, leading to reduced p38 MAPK activity and disrupted erythroid differentiation.

The paper identifies PRMT5 as a synthetic lethal target with gemcitabine in pancreatic cancer using CRISPR screening in a PDX model.

The paper identifies and characterizes ORF3d, a novel overlapping gene in SARS-CoV-2, showing its presence in pangolin-CoVs and its evolutionary significance.

The paper introduces a hybrid light-sheet microscope that enables versatile multi-scale imaging of cleared tissues with varying resolution, geometry, and compatibility requirements.

This study creates a single-cell transcriptome atlas of a non-human primate to explore SARS-CoV-2 targets and immune responses, identifying potential therapeutic targets and mechanisms linking IL6 to viral entry.

This study identifies SARS-CoV-2 as a recombinant virus of bat and pangolin coronaviruses and reports ongoing mutations in its genome.

OLGenie estimates natural selection in overlapping genes to identify functionally constrained gene pairs with high accuracy.

The paper identifies endogenous foamy viruses in two stork species, showing independent integration events in birds and expanding the known taxonomic distribution of foamy viruses.

The paper examines deviations from Hardy-Weinberg Equilibrium at CCR5-Δ32 in UKB WES and gnomAD data, finding a deficiency of homozygotes and supporting a deleterious effect of the deletion mutation.

This study identifies MnJ, a colloidal manganese salt, as a potent universal adjuvant that induces both humoral and cellular immune responses, including CTL activation and mucosal immunity.

PIRD is a database that collects and stores annotated TCR and BCR sequencing data, along with tools for visualization and analysis.

The paper analyzes gene panel sequencing data from 829 Chinese high-risk breast cancer patients to identify pathogenic variants and variants of uncertain significance across 115 hereditary cancer susceptibility genes.

This study examines gut microbiome differences between lung cancer patients and healthy individuals, finding altered microbial composition but unclear links to cancer development.

The paper discovers a new endogenous foamy virus in tuatara, showing co-divergence with its host and filling a gap in retrovirus evolution.

The paper examines diminishing returns epistasis in yeast across environments, finding it widespread and showing environmental quality affects mutation benefits independently of fitness.