X. Zhang

This study investigates the antibacterial properties of cannabinoids, showing efficacy against MRSA and Gram-negative bacteria, and their potential as therapeutic agents.

This study links cellular virological stages in chronic hepatitis B to liver fibrosis progression through spatial and functional analysis of viral and host gene expression.

This study shows that recessive deleterious variants can increase false positives in detecting adaptive introgression, but most signals remain robust, with HYAL2 and HLA being particularly affected.

The paper identifies ALPPL2 as a highly specific tumor cell surface antigen for mesothelioma and demonstrates its therapeutic potential through an antibody-drug conjugate.

This study shows that a CXCR4-binding PET tracer accumulates in atherosclerotic plaques due to endothelial CXCR4 expression, linking endothelial injury to monocyte recruitment.

The paper identifies endoimmune cells, a novel subpopulation of endothelial cells in zebrafish, using single-cell RNA sequencing and shows their involvement in immune responses.

The paper reports the cryo-EM structure of the human TIM22 complex at 3.7 angstrom resolution, revealing its architecture and potential mechanism for protein import.

This study presents methods to incorporate full-length HIV-1 Env into lipid assemblies for structural analysis, revealing the quaternary epitope of an MPER antibody and Env tilting during neutralization.

This paper shows that increasing cryo-EM sample freezing temperature reduces beam-induced motion and improves reconstruction resolution by including more undamaged initial frames.

This study identifies SCR's role in promoting root growth by enhancing cell elongation and maintaining redox homeostasis through suppression of oxidative stress response.

This study shows that motorized shoes can induce locomotor adaptation similar to split-belt treadmill training, suggesting portable devices can study sensorimotor adaptation outside the lab.

This paper uses single-cell RNA sequencing to characterize neutrophil heterogeneity and maturation during homeostasis and bacterial infection, revealing distinct subsets and their functional transitions.

This study shows that Klf5 downregulation in VSMCs leads to mitochondrial fission and senescence by reducing eIF5a, which preserves mitochondrial integrity.

This study shows that P16 methylation increases cancer cell sensitivity to palbociclib, a CDK4/6 inhibitor, through experimental and pharmacogenomic analyses.

This study shows that the in vitro and in vivo cellular uptake and trafficking of miktoarm copolymer nanomicelles (MCNs) correlate, with FRET efficiency changes reflecting transport mechanisms and probe uptake behavior.

The paper identifies a lipid-dependent phosphorylation cascade involving PDK1 and D6PK that regulates PIN-mediated auxin efflux in Arabidopsis development.

This study investigates how temperature affects RNA editing in grape organelles, finding that editing levels decrease with rising temperature and that PPR gene expression declines, potentially contributing to stress adaptation.

This study shows that Crif1 promotes radiation-induced osteoporosis in mice by increasing RANKL expression and that targeting Crif1 could be a therapeutic strategy.

The paper uses single-cell RNA-seq to analyze human Wharton’s Jelly-derived MSCs, identifying heterogeneity in gene expression and potential marker genes for potency.

The paper investigates how entomopathogenic nematodes develop resistance to benzoxazinoid metabolites sequestered by a maize herbivore, showing increased infectivity towards the herbivore.

This study shows that neogambogic acid inhibits osteosarcoma by targeting the USP9x/SOX2 axis through ubiquitin proteasome-mediated degradation of SOX2.

The paper analyzes 2045 MAGs from activated sludge to identify plant- and environment-specific features using machine learning, achieving 96.6% accuracy in distinguishing AS MAGs from others.

This study conducts a meta-analysis showing opioids increase fracture risk by 78% in patients with chronic noncancer pain.

The paper presents the structure of nucleotide-bound Tel1ATM, revealing molecular mechanisms of inhibition and explaining disease-related mutations.

The paper identifies proteasome-dependent degradation of PAL as a mechanism linking glucosinolate and phenylpropanoid biosynthesis through regulation of KFB genes.

The paper develops a convergent hybrid phase ligation strategy for synthesizing large proteins, demonstrating its effectiveness with the 212-residue histone H1.2.

This study shows glycogen metabolism via the oxidative pentose phosphate pathway (OPPP) initiates photosynthesis in cyanobacteria by modulating NADPH levels during dark-light transitions.

This study identifies a Clostridia-rich microbiota as a contributor to excessive bile acid excretion in IBS-D patients through metagenomic and metabolomic analyses.

The paper shows CDK1 phosphorylates ULK1-ATG13 in mitosis to regulate autophagy and Taxol sensitivity, with implications for cancer therapy.

This study demonstrates that delivering mesenchymal stem cells (MSCs) in a collagen gel scaffold enhances their migration to damaged sites and promotes wound healing without systemic side effects.