Y. He

This study engineers the STING protein as a delivery system to enhance CDN delivery and restore STING signaling in cancer cells.

This study shows UV-nail polish dryer radiation causes DNA damage and somatic mutations in mammalian cells, with mutagenic patterns linked to reactive oxygen species.

This study identifies prognostic non-tumor cell types in glioblastoma by analyzing gene expression across four cohorts, revealing risk and protective factors associated with immune response clusters.

This study shows that helical pitch size determines microtubule plus end dynamic instability through stochastic simulations, finding that 1.5 dimer pitch optimizes growth and shrinkage phases.

The paper introduces IRCA to infer metabolite conversion networks from single-cell Raman spectra of isogenic populations without time-series data.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper uses high-throughput assays and machine learning to model biophysical interactions governing protein domain compatibility in fusion proteins.

This study identifies Cwl0971 as a peptidoglycan hydrolase in C. difficile that affects autolysis, toxin release, sporulation, and pathogenicity.

This paper introduces a method to assess cell viability without staining using phase imaging and deep learning, achieving 95% accuracy in distinguishing live and dead cells.

This study identifies impaired microbial detoxification in autistic children using a quasi-paired cohort strategy, linking it to mitochondrial damage and potential therapeutic strategies.

The paper develops a method to delete large genomic regions in Nannochloropsis oceanica, showing that non-essential regions can be removed without affecting key traits.

This study uses molecular dynamics simulations to show that ligand binding to the PICK1 PDZ domain induces electrostatic allostery, altering its dynamics and potentially affecting PICK1 function.

This study shows that middle-aged mice undergoing sleeve gastrectomy experience fat mass regain in the second month post-surgery, while plasma leptin levels remain low.

This study shows that sleeve gastrectomy in middle-aged obese female mice leads to sustained weight loss and improved glucose tolerance, associated with increased brown adipose tissue metabolism.

This study designs engineered proteases that specifically degrade active RAS by cleaving a conserved sequence in switch 2, showing efficacy in vitro and in human cell culture.

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

This study shows ZmMTOPVIB is essential for DSB formation and bipolar spindle assembly in maize meiosis, with conserved functions in monocots.

The paper identifies four dominant mutations, three significant multi-site co-mutations, and a 5'UTR CpG escape mutation that drive the rapid evolution of SARS-CoV-2.

This study shows that metformin chlorination byproducts are toxic to nematodes, human cells, and mice, and identifies boiling and activated carbon as effective removal methods.

This study identifies SARS-CoV-2's high fusogenic activity via ACE2 receptor and designs a potent lipopeptide inhibitor, IPB02, targeting the HR2 region of the spike protein.

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

The paper develops an IP-MS assay to identify slow-growing mycobacterial species in early MGIT cultures using species-specific antibodies.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

This study shows that combining chidamide and doxorubicin synergistically inhibits anaplastic thyroid carcinoma by inducing autophagy via the PI3K/Akt/mTOR pathway.

This paper develops a novel mouse model for SARS-CoV-2 infection and evaluates the protective efficacy of an RBD-based subunit vaccine.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study shows that antibodies from SARS-CoV survivors and immunized animals neutralize SARS-CoV-2, suggesting potential for broad-spectrum vaccines against emerging coronaviruses.

The paper develops an interpretable machine learning framework to identify gut microbiome features predictive of type 2 diabetes, validated across multiple cohorts and linked to metabolic outcomes.