Y. Sun

This paper introduces engineered MHC-I molecules with enhanced stability and peptide exchange capabilities across multiple HLA allotypes, enabling improved antigen screening and TCR analysis.

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

This paper constructs a syntelog-based pan-genome of rice using long-read sequencing to study domestication and de-domestication, identifying introgression events and domestication genes.

This study shows GPR4 knockout reduces intestinal inflammation and tumor development in colitis-associated colorectal cancer mouse models.

This paper introduces mNODE, a neural ODE-based method predicting metabolomic profiles from microbial composition, showing superior performance and interpretability across human and environmental microbiomes.

The paper introduces SAGES, a method using structural features to analyze proteomic and transcriptomic data, revealing dynamic expression of intrinsically disordered regions in breast cancer and drug perturbation relationships.

The paper reports low neutralizing antibody levels against influenza A H1N1 and H3N2 viruses in adults during the Omicron outbreak, emphasizing the need for influenza vaccination.

This study shows homocysteine increases hepatocyte autophagy by upregulating TFEB through DNMT3b-mediated DNA hypomethylation of the TFEB promoter.

This study examines how plant selection and ecological microhabitats influence the microbiomes of revegetated shrubs, finding that microhabitats, not plant species, primarily drive microbial community composition.

The paper introduces WIT, a context-aware transformer model for whole slide image classification, achieving higher accuracy than baseline methods across multiple cancer datasets.

This study shows that ethyl maltol disrupts iron homeostasis in SH-SY5Y cells, leading to decreased viability and DNA damage via the p53 pathway, with APP mitigating these effects.

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study uses single-molecule imaging to show SUN2 dynamics and distribution on the nuclear envelope are regulated by actomyosin contractility and laminA/C network, affecting mechano-sensitive gene expression.

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

This study shows TR4 promotes RCC cell-derived exosomal ADAM15, which activates EGFR in endothelial cells and reduces Sunitinib efficacy, and demonstrates that targeting this pathway enhances Sunitinib effectiveness.

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

The paper quantifies global nitrogen uptake and use efficiency in plants using regression models and remote sensing data, finding that NUE is influenced by climate and allocation patterns.

The paper identifies SLK splicing dysregulation in cancers, showing SLK-L promotes metastasis while SLK-S inhibits it, with Rbfox2 regulating this splicing event.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

This study describes a new saurosphargid species from the Early Triassic of South China and presents a phylogenetic analysis clarifying the relationships of sauropterygians and their evolutionary history.

This study identifies how avian-origin H3N2 influenza viruses adapt to dogs, acquiring traits that increase their potential to infect humans.

This study investigates how erastin and other ferroptosis inducers affect global metabolism, finding that nucleotide metabolism is significantly impacted and linked to cysteine availability.

This study investigates the metabolism of the PET tracer [18F]3F4AP, identifies its metabolites, and evaluates the effect of deuteration on its stability.

This study identifies DVG generation in SARS-CoV-2 and links it to IFN stimulation and persistent infection, showing higher DVG levels in symptomatic patients.

The paper introduces the Image Data Explorer, a web tool for interactive exploration of image-derived data in bioimage analysis.

The paper investigates the conformation of N2B-us and its force-dependent interaction with FHL2 using AlphaFold2 and single-molecule experiments, revealing a stable structural domain and mechanosensitive binding.

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.