Y. Zhang

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This study examines the impact of Hurricane Harvey on water quality and microbial communities in Houston waterbodies, finding elevated fecal bacteria and shifts in microbial structure that took at least a month to recover.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

The paper uses GSVA and AI to identify a gene set and immune signals associated with poor prognosis in HBV-related diseases.

This paper identifies a broadly neutralizing antibody, STI-9167, effective against SARS-CoV-2 variants including Omicron and Omicron + R346K, and describes its development for clinical trials.

This study uses metagenomics to characterize microbial community structure and metabolic capacity in Bamucuo, Tibet, identifying new species and metabolic pathways.

This study shows that overexpressing CDKN1A in macrophages enhances their ability to phagocytose leukemic cells, leading to pro-inflammatory reprogramming and improved survival in mouse models.

This paper develops an integrated electrochemical liquid biopsy platform for detecting cancer exosomes from blood using a rational engineering strategy.

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

This paper reviews studies on lipid transfer proteins and develops quantitative models to explain lipid transfer kinetics and membrane contact site formation mechanisms.

The paper develops models to explain how force affects TCR signaling and antigen discrimination by analyzing bond characteristics of TCR-pMHC interactions.

This paper reports the high-titer production of aromatic amines in engineered E. coli by optimizing carbon source and deleting fermentation byproduct genes.

This study identifies an NO-to-H2O2 switch in diabetic coronary vasodilation mediated by miR-21, contributing to microvascular dysfunction.

This study uses single-cell RNA sequencing to analyze cardiac immune cell dynamics after myocardial infarction in mice, identifying key immune subsets and their roles in disease progression.

BlenderPhotonics provides an open-source tool for 3-D meshing and photon simulations in complex tissues using Blender and MMC, enabling user-friendly and efficient modeling.

The paper describes a microfluidic method to create cell-laden alginate microgels with tunable compositions by adjusting cross-linker concentration.

The paper develops a high-throughput method to screen restriction endonucleases using microfluidics and bacterial SOS response, achieving 30-fold enrichment of target genes in one hour.

This paper introduces a PCR-free, label-free method for single-molecule DNA detection using an in vitro N-hybrid system in microfluidic drops, achieving high specificity through protein interactions.

The paper shows that BSMV γb protein targets NbTRXh1 to reduce its reductase activity, impairing SA defense gene expression and enhancing viral movement.

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

This study uses single-particle tracking to analyze dynein motor behavior in live neurons, revealing that dynein switches between 1-5 motors and requires 2 ATP hydrolysis per step.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

The paper shows phosphoantigens glue BTN3A1 and BTN2A1 together, initiating gamma-delta T cell activation through intracellular signaling.

This paper introduces MATE, a label-free 3D histological imaging technique for whole organs, enabling high-resolution visualization and quantitative analysis of tissue structures without staining or clearing.

The paper identifies potent monoclonal antibodies that neutralize the B.1.1.529 SARS-CoV-2 variant and reveals structural mechanisms enabling their effectiveness.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

This study shows elevated ozone and nitrogen addition increase poplar rust severity by altering phyllosphere microbial communities, with clone-specific responses observed.

This study shows that the PIKA-adjuvanted SARS-CoV-2 spike protein vaccine YS-SC2-010 maintains high neutralizing activity against Omicron and other variants for up to 596 days post-vaccination in animal serum.