Y. Zhang

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This paper introduces a heat-shock protocol for wheat transformation that significantly improves efficiency using BBM-WUS, reducing the time to obtain transgenic plants to 60 days.

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.

This study identifies dual-site interactions between Sso2 and Sec3 that drive secretory vesicle fusion in yeast.

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

This study shows E. coli can use DNA as a nitrogen source for growth, outperforming Bifidobacterium bifidum, and ingests long DNA directly without altering its length.

This study identifies tryptamine, a gut microbiota-derived metabolite, as a contributor to insulin resistance in type 2 diabetes through TAAR1-ERK signaling.

This study identifies Ruminococcus gnavus as a gut bacterium that contributes to IBS-D by increasing serotonin biosynthesis through phenethylamine production.

This paper introduces a method to control CRISPR-Cas gene editing using light-activated circular guide RNAs, enabling precise spatial and temporal gene editing in cells and embryos.

This study shows how natural selection rapidly reshapes developmental gene regulatory networks in sea urchins with divergent life histories, revealing evolutionary changes in gene regulation and chromatin status.

This study investigates the association between RSV genetic variations and disease severity in infants, finding significant links between phylogeny and specific protein variations in different subtypes.

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.

This study shows that methionine metabolism regulates EBV epigenetic states and latency in B-cells, with methionine restriction impairing viral gene silencing and immune evasion.

This paper introduces Spinning Disk Multifocal Microscopy (SDiM) for high-speed, high-resolution imaging of large biological surfaces, demonstrating its application in cortical and immune cell studies.

This study reports cryo-EM structures of NMUR1 and NMUR2 bound to NMU and NMS, revealing peptide selectivity mechanisms and activation principles for drug design.

This study shows that an Omicron-matched DNA vaccine booster enhances cross-reactive immunity against Delta and Omicron variants in mice compared to an ancestral strain booster.

The paper identifies APE-1 as a modulator of PP1 activity in C. elegans, showing it localizes PP1 to junctions and modulates phosphatase output through its ankyrin repeats.

The study compares antigen-antibody interactions at different states using QDB, showing conformational epitopes dominate interactions, challenging Western blot as a validation tool for IHC and ELISA antibodies.

The paper compares proton transfer paths to the QA and QB sites in Rb. sphaeroides reaction centers using molecular dynamics, finding QA is isolated while QB has a complex network involving multiple surface residues.

This study identifies small molecule modulators of the SWELL1-LRRC8 complex that improve glycemic control and prevent NAFLD in murine T2D by restoring insulin signaling and secretion.

This study demonstrates that MYCN and BCL2 enhance interspecies chimerism with human pluripotent stem cells, enabling the generation of functional human blood progenitor cells in chimeric embryos.

This study identifies alkaloids and related intermediates in Dendrobium officinale using SPE-HPLC-LTQ-Orbitrap and database alignment.

This study compares quantification methods for tumor tissue phosphoproteomics and finds TMT offers highest precision, spike-in-SILAC balances features best, and LFQ provides most identifications.

This study shows that aucubin promotes functional recovery after spinal cord injury by reducing inflammation and neuronal apoptosis through the TLR4/NF-κB pathway and mitochondrial protection.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

LIFE-Seq is a method for analyzing transgene integration in GMOs using DNA probes and PacBio sequencing, offering improved accuracy and cost-effectiveness compared to whole-genome sequencing.

This study optimizes urinary extracellular vesicle isolation methods and detects radiation-induced metabolomic changes using mass spectrometry.

This study compares phenotypic and transcriptomic responses of sun- and shade-loving plants to sunlight and dim-light conditions, finding that shade-loving ginseng shows lower phenotypic plasticity but higher photosynthetic efficiency under dim light.

This study identifies FOXM1 as a transcription factor that specifies and loads chromatin DNA fragments into extracellular vesicles via an LC3-dependent autophagosome-MVB pathway.

The paper introduces DeepWonder, a deep learning tool for rapid and accurate neuron detection in widefield calcium imaging data, achieving faster processing and improved signal-to-background ratio compared to traditional methods.