Z. Chen

This paper shows that eliminating monocyte chemoattraction increases neutrophil infiltration in glioblastoma, promoting tumor aggression, and that targeting both monocytes and neutrophils improves survival in mouse models.

This study characterizes the functional domains of Vip3Aa protein from Bacillus thuringiensis and shows how modifying protease sites enhances its insecticidal potency against Spodoptera frugiperda larvae.

This study reports the cryo-EM structure of the NuA4 complex bound to a nucleosome, revealing its mechanism of nucleosome recognition and transcription coactivation.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study develops an injectable hydrogel with homogenous mesenchymal stem cells to treat severe spinal cord injury in rats, showing improved functional recovery compared to intrathecal delivery.

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

This paper introduces a graphene biointerface for in vivo cardiac electrophysiology, demonstrating its use in sensing, stimulation, and treatment of arrhythmias.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

The paper defines the STX binding code for saxiphilin proteins and identifies new members of the Anuran saxiphilin family.

This study shows that the C2b domain of AC9 auto-inhibits basal cyclic AMP production and prevents GsR stimulation, with a mutation enabling both increased basal activity and GsR responsiveness.

This paper reports the development of two DARPins, FSR16m and FSR22, that potently neutralize SARS-CoV-2 variants, including emerging ones, with efficacy comparable to therapeutic antibodies.

This paper presents an experimental microfluidic model to simulate herd immunity for a human coronavirus by varying cell proportions and observing transmission dynamics.

This study analyzes antibody evasion by SARS-CoV-2 Omicron subvariants BA.2.12.1, BA.4, and BA.5, finding BA.4/5 shows greater resistance to neutralizing antibodies than BA.2.12.1.

This study identifies LRP8 as a targetable vulnerability in MYCN-amplified neuroblastoma by showing its role in selenocysteine import and resistance to ferroptosis.

This study uses cryo-electron tomography to reveal the asymmetric protein complexes in mammalian sperm axonemes, explaining their unique flagellar beating pattern.

This paper introduces flexible electro-optical devices for simultaneous cardiac mapping and modulation, demonstrating their functionality in real-time spatiotemporal control of cardiac activity.

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

This paper introduces a new fluorescent marker, PKMO, enabling 3D live-cell STED nanoscopy of mitochondria with improved photostability and reduced phototoxicity, allowing multiplexed imaging of mitochondrial dynamics and interactions.

The paper identifies a collagen glucosyltransferase in Acanthamoeba Polyphaga Mimivirus through genomic and structural analysis, revealing its unique enzymatic activity and substrate specificity.

This study identifies EstG, a novel esterase in Caulobacter crescentus that protects against cellular stress by acting on cyclic osmoregulated periplasmic glucans rather than the cell wall.

The paper identifies a paracrine IL-1β/IL-1R1 circuit between myeloid and tumor cells that drives glioblastoma progression and shows that antagonizing this circuit reduces tumor growth and extends survival.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This paper identifies a potent SARS-CoV-2 antibody, 553-49, that neutralizes the Omicron variant by targeting a conserved epitope and disassembling spike trimers.

The paper identifies Lnc956 as a non-coding RNA that forms a complex with TRIM28 and HSP90B1 to prevent replication fork collapse and maintain genomic stability in mouse embryonic stem cells.

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

This study identifies two phosphosites on the kinase WNG1 that are essential for its activity and reveals that its activation is triggered by increased ATP concentration upon trafficking to the parasitophorous vacuole.

This study identifies hypoxia-driven immunosuppression in glioblastoma by tracking TAM dynamics and reveals niche factors that promote immunotolerant states and poor prognosis.