Z. Chen

This study presents the first crystal structure of the Vip3A toxin, revealing its domain organization and glycan binding specificity, which informs its insecticidal mechanism and potential for improved bio-insecticides.

This study shows that Swi6 condensation provides mechanical stiffness to the nucleus, demonstrating a mechanical function of biomolecular condensates.

The paper identifies the role of clathrin's N-terminal domain in CME and develops a peptide inhibitor that specifically blocks CME without affecting other endocytic processes.

This study uses multiplexed imaging and transcriptomics to identify immunosuppressive features in TB granulomas and blood, linking local and systemic immune responses.

The paper identifies Fli1 as a transcriptional regulator that limits effector CD8 T cell differentiation during infection and cancer, showing its deletion enhances TEFF responses and immunity.

The paper identifies distinct immunotypes in COVID-19 patients through high-dimensional cytometry, linking them to disease severity and potential therapeutic implications.

The paper presents a physics-based model predicting T cell epitope immunogenicity across pathogens, finding that only some SARS-CoV-2 epitopes are immunogenic and some are shared with low-pathogenicity coronaviruses.

This paper identifies a potent neutralizing antibody targeting the N-terminal domain of SARS-CoV-2 Spike protein, revealing it as a new therapeutic target.

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

This study shows Mg2+ promotes bone regeneration initially by modulating macrophage activity but later inhibits bone formation through NF-κB activation and reduced hydroxyapatite precipitation.

This study shows zoledronate extends lifespan and healthspan in Drosophila by modulating the mevalonate pathway through FOXO-dependent mechanisms.

This paper develops freeze-dried PCR mixes for SARS-CoV-2 detection that can be stored at room temperature, maintaining sensitivity and specificity for up to 28 days.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

This study investigates how thermal stress and acrolein, a smoke toxin, affect airway epithelial barrier function by altering ion transport pathways and tight junction integrity.

The paper identifies a 22-gene expression signature to measure glycolysis activity across 25 cancer types, showing its correlation with hypoxia, genomic instability, and tumor proliferation.

This paper demonstrates magnetoelectric materials enable miniature, wireless neural stimulators operating at therapeutic high-frequencies for treating Parkinson's disease in rodents.

This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

This study expresses an Arabidopsis remorin protein in mammalian cells to form PD-like structures that transport macromolecules and resemble plant plasmodesmata in structure and function.

This paper reveals the structure of human beta-2 glycoprotein I and shows that its elongated, flexible conformation allows autoantibodies to recognize an epitope without phospholipids.

The paper develops a discrete dynamic model for human epidemics and identifies key parameters influencing total cumulative cases through sensitivity analysis.

The study identifies AD1, a 3-KETOACYL-CoA SYNTHASE gene regulated by FUSED LEAVES1, as essential for cuticle formation and organ separation in maize.

This study shows dual IL-6 and CTLA-4 blockade regresses pancreatic tumors via CD4+ T cells and CXCR3-dependent mechanisms.

The paper introduces DASC, a method to distinguish abortive clathrin coats from clathrin-coated pits in live-cell imaging, enabling sensitive analysis of CME progression in EAP knockdown conditions.

The paper was withdrawn due to lack of full author consent and is not intended for citation.

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

The paper identifies dozens of QTL for leaf angle across eight leaves in maize under three environments, revealing genetic architecture differences at various canopy levels.

This study shows that deleting Chop/Ddit3 in β-cells reduces ER stress and corrects fatty liver disease in T2D without affecting glucose homeostasis.

The paper identifies RGS1 as a marker and promoter of T cell exhaustion in multiple cancers using single-cell transcriptome analysis and validates its association with poor prognosis.