Z. Chen

This study shows RTR-1, a compound from Rhodomyrtus tomentosa, inhibits gastric cancer cell proliferation by inducing ER stress and blocking the STAT3 pathway, while causing G2/M phase cell cycle arrest.

The paper uses a synthetic system to study maize auxin signaling, showing that the circuit is sensitive and functionally similar to Arabidopsis.

MACS is a rapid aqueous clearing method that enables 3D imaging of intact organs with high transparency and compatibility with lipophilic dyes.

This study shows that rabies virus glycoprotein suppresses gastric cancer migration by inhibiting the 7-nAChR-MEK/ERK-EMT pathway.

The paper analyzes Ca2+ regulation in horse gluteus muscle, finding high SLN RNA but low SLN protein, suggesting a non-coding role, and enhanced SR Ca2+ transport.

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

This study compares cold resistance in two discus fish species using antioxidant indexes, finding interspecific variation linked to environmental adaptation.

This study examines how incomplete sampling affects diversification rate estimates in rosids and finds that no method is fully robust to poor sampling, with BAMM being least sensitive to moderate missing taxa.

This paper introduces CLEAR-dPCR, a lossless and contamination-free digital PCR technology that improves accuracy and dynamic range compared to existing platforms.

The paper investigates the role of xa5 in BLS resistance by analyzing transcriptome changes in Xa5-RNAi rice lines compared to wild-type, finding enhanced cell death gene responses.

The paper identifies JMJD6 as a protease that cleaves MePCE, releasing P-TEFb from the 7SK snRNP complex to enable Pol II-CTD phosphorylation.

The paper maps nucleosome barriers' topography and Pol II dynamics using single-molecule assays and reveals how H2A.Z and uH2B modify barrier height and width, affecting transcription.

The paper uses MD simulations to study ligand transport by P-gp and shows lipids also play a role in this process.

The paper constructs a five-locus supermatrix from GenBank data to explore rosid phylogeny, finding improved resolution but also highlighting sampling biases and limitations in current data.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

This study develops a finite element model of bilateral human semicircular canals to analyze cupular expansion and deflection during head rotation, showing their mechanical roles in vestibular function.

This study identifies a novel O_SCPCAPLC_SCPCAP-serine exporter, SerE, and its positive regulator NCgl0581 in C. glutamicum, showing their roles in amino acid export and transcriptional regulation.

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

This paper develops a CRISPR-Cas13b-based tool to specifically demethylate m6A modifications on target mRNAs, enhancing their stability and demonstrating efficient gene regulation with minimal off-target effects.

This study identifies RHAMMB as a key driver of pancreatic tumor metastasis, showing its upregulation in PNETs and correlation with poor patient survival through EGFR signaling.

This study shows that formaldehyde inhibits osteoblast proliferation and migration via the FoxO1 signaling pathway in mouse cells.

This study shows that carbonic anhydrase IX (CA IX) contributes to pH regulation and glycolytic phenotype in breast cancer cells through a non-catalytic function, independent of its enzymatic activity.

The paper identifies differentially expressed proteins in tumor-associated vascular endothelial cells of colorectal cancer and links some to angiogenesis and metastasis.

The paper develops a microchip-based sequential secretion assay to analyze protein dynamics in single human macrophages, revealing distinct activation modes and states dependent on basal conditions.

This study combines Azospirillum brasilense inoculation with seed priming to enhance germination and seedling growth in aged grass seeds, finding that H2O2 priming with optimal bacterial concentration and time is most effective.

This study shows MAIT cells protect against lethal influenza infection by accumulating and being activated early, with their absence increasing mortality in mice.

This study investigates the isoform-specific inhibition of CA IX and CA XII by benzene sulfonamides in breast cancer cells, finding greater specificity for CA IX and disconnect between CA activity and growth inhibition.

This study examines how acid rain affects soil microbial communities and plant performance, finding that Pisolithus inoculation alters soil properties and microbial composition under severe acidic conditions.

The paper examines how impulsivity and mindset affect science self-efficacy and STEM interest in adolescents, finding that mindset can counteract the negative effects of impulsivity.