C. Li

TANKBind improves drug-protein binding structure prediction by incorporating trigonometry constraints and functional block segmentation, achieving better performance than existing methods.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

This study analyzes the adaptive immune landscape of T-cell mediated rejection in human kidney allografts using RNA sequencing and identifies key molecular features associated with rejection.

The paper identifies a new endolysosome process, LEA, where autophagosomes are engulfed by extending arms (LF) without fusion, and describes the molecular markers of engulfed autophagosomes.

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

This study shows metformin reduces Cyp26a1 expression, increasing atRA levels and decreasing pro-tumor CD8+ T cells, thereby preventing hepatocarcinogenesis in a mouse model.

This study describes an Early Triassic sauropterygian skeleton, identifies its phylogenetic position, and highlights the ancestral body plan and adaptive radiation of marine reptiles.

This paper reports the crystal structure of Rubella virus protease and demonstrates its protease and deubiquitylation activities, providing insights for antiviral drug development.

This study presents a chemomechanical model of sperm swimming that identifies two distinct modes of locomotion with different waveforms and velocity patterns based on dynein activity.

This paper identifies Coq1 as a target of a bisphosphonate that inhibits Toxoplasma gondii growth and protects mice from infection.

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

This paper identifies two conserved regions on the Omicron RBD recognized by broadly neutralizing antibodies and develops an inhalable bispecific antibody with broad neutralization and therapeutic efficacy in mice.

This study examines how vaccination affects influenza A virus reassortment and genetic variation in pigs, finding reduced reassortant viruses in vaccinated pigs but no significant impact on genetic diversity.

The paper develops a multiplexed in vivo approach to identify driver genes in SCLC using CRISPR/Cas9 and lentiviral barcoding, finding TSC1 as a robust tumor suppressor.

This study identifies TraB1 as a novel EMCS component in Arabidopsis that regulates both ER-mitochondrial tethering and mitophagy, essential for mitochondrial function and stress recovery.

This paper shows that Hinokitiol reduces fungal load and inflammation in Aspergillus fumigatus keratitis by altering gene expression and inhibiting fungal growth.

This study identifies OsIRO3 as a negative regulator of Fe homeostasis in rice by repressing OsIRO2, a positive regulator of Fe uptake.

This study shows that BA.2 causes stronger antibody evasion than BA.1, particularly in SARS convalescents, and identifies key mutations responsible for this escape.

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study identifies OsDML4 as a demethylase gene whose knockout under high temperature causes floury endosperm by altering DNA methylation and gene expression in rice.

This paper develops self-powered artificial cell colonies that mimic muscle behavior through actin polymerization and depolymerization, showing reversible deformation and collective contraction.

This paper identifies TS-984 as a potent inhibitor of the SARS-CoV-2 spike protein-ACE2 interaction through a high-throughput screening platform and in vitro validation.

This study constructs a single-cell transcriptome atlas of multiple myeloma patients stratified by R-ISS, identifies PC subsets and immunotargets, and links them to prognosis and EBV infection.

This paper introduces a new collective variable based on graph theory to quantify water wire connectivity and proton translocation in confined spaces, revealing that water connectivity, not just presence, is critical for proton transport.

This study shows dihydroartemisinin (DHA) enhances anti-PD-1 therapy in hepatocellular carcinoma by inhibiting YAP1 and disrupting immune evasion through PD-L1, JAK1/STAT1, and JAK3 pathways.

This study evaluates how in vitro digestion of meat and soy proteins differs under gastrointestinal conditions mimicking elderly achlorhydria compared to adults, showing reduced hydrolysis and distinct protein degradation patterns in elderly conditions.

This study uses omics approaches to show Hematodinium parasites modulate crustacean immune responses through miRNA and proteomic changes.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.