C. Li

This study uses a coarse-grained model to investigate the biophysics of lipid droplet formation, showing that membrane rigidity and asymmetric tension influence TG nucleation and budding direction.

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This study identifies RAS/PI3K pathway activation as a common driver in oncogene-negative lung adenocarcinomas and shows these tumors are vulnerable to targeted therapy.

The paper identifies an ultrathin calcified region in human knee osteochondral interface tissue with two-layered micro-nano structures and exponential modulus increase, enhancing energy dissipation and fatigue resistance.

This study identifies Lin28a's role in rejuvenating muscle stem cells through mitochondrial optimization and epigenetic regulation, enhancing their regenerative capacity.

This study shows that Esm-1 reduces albuminuria and podocyte injury in diabetic mice, possibly through inhibiting interferon signaling.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

This study uses a semi-synthesis approach to generate N-terminal acetylated HMGB1 proteins and shows that this modification affects its interaction with heparin and stability.

This study investigates how cockroaches adjust their body and appendages to traverse cluttered obstacles, finding that leg sprawl reduction significantly lowers the energy barrier for locomotor transitions.

This study uses multiscale modeling to show how proton flux drives the conformational changes and ligand transport in proton-coupled peptide transporters.

The paper introduces a terrain treadmill to study animal locomotion through large obstacles over large spatiotemporal scales with high-resolution observations.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

The paper identifies OsSWEET11b as a rice gene involved in male fertility and susceptibility to bacterial leaf blight, showing its role in sucrose transport and Xoo virulence.

The paper identifies miR-106b-5p in exosomes from Mtb-infected macrophages that promote Mtb survival by regulating lipid metabolism and apoptosis in uninfected macrophages.

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

This study identifies WAPO-A1 as the causal gene for a QTL affecting spikelet number per spike in wheat and shows that the H2 haplotype significantly increases grain yield.

This study develops a high-throughput method to produce functional prototissues that generate nitric oxide, inducing vasodilation in rat blood vessels.

This study identifies LENG8 as an mRNA processing factor that regulates mitochondrial activity by controlling mRNA nuclear export and mitochondrial protein expression.

This study shows H2O2 levels regulate Shh trafficking and that Shh controls H2O2 synthesis via a noncanonical BOC-Rac1 pathway, impacting tissue patterning.

This study investigates how plasma-activated water (PAW) affects the viability and cellular responses of Fusarium graminearum, finding significant inhibition of microbial activity and damage to cell wall, membrane, and mitochondria.

The paper uses single-cell sequencing to analyze glioma-associated microglia and macrophages, revealing their distinct roles in tumor progression and clinical outcomes.

The study tracks IgG antibody levels against SARS-CoV-2 RBD in convalescent plasma donors over 12 months, showing sustained positivity and gender/age-related differences.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

OsciDrop generates size-tunable, monodisperse droplets on demand without microfabrication, enabling chip-free droplet assays for applications like virus quantification.

The paper identifies RNA editing of the BOSS gene in tomato that regulates flowering by producing functionally distinct transcripts.

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

This study shows that mechanical forces in Vibrio cholerae biofilms drive a reorientation cascade, creating a core-rim structure through differential growth and compressive stresses.