C. Wang

This study identifies LPD-3 as a megaprotein that regulates insulin-mTOR signaling and aging in C. elegans by modulating sphingolipid and insulin pathways.

This study identifies chloride ions as essential determinants of ferroptosis, showing that extracellular chloride levels influence lipid peroxidation and cell death.

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

This study identifies GmAlfin09 as a transcription factor that enhances ER stress resistance in soybean by upregulating GmPRDX6, which reduces ROS levels and maintains ER homeostasis.

The paper shows that sequential reperfusion with high CO2 then normal CO2 reduces cardiac ischemic reperfusion injury in rat hearts by altering metabolic pathways.

This study characterizes human glioblastoma organoids using multi-omics analysis and identifies drug targets linked to glycerol lipid reprogramming.

This paper presents a chiral graphene quantum dots platform for efficient drug loading into exosomes, achieving high loading efficiencies for both hydrophobic and hydrophilic drugs.

This paper identifies PfGCN5 as a key regulator of stress responses in Plasmodium falciparum, showing its role in artemisinin resistance and sensitivity to various stress conditions.

The paper uses in situ serial Laue diffraction to image spin-coupled electron densities in a [4Fe4S] iron-sulfur cluster during light-induced redox reactions.

This study identifies HERC5-catalyzed ISGylation of cGAS as a mechanism that enhances antiviral innate immunity by modulating the cGAS-STING pathway.

The paper identifies and characterizes ILC-like cells in porcine jejunum using scRNA-seq and flow cytometry, revealing subtype classifications and shared features with human ILCs.

This study shows that reactivation of human endogenous retroviruses during aging promotes cellular senescence and tissue degeneration, and that blocking this reactivation can alleviate aging.

The paper develops a sensitive and selective RPLC-MS/MS method to quantify insulin secretion from islet organoids, overcoming carry-over and sensitivity issues with low-volume samples.

The paper identifies lipoproteins transported to the cell surface via LptDE and reveals a crosstalk between Lpt and Lol pathways in Gram-negative bacteria.

This study identifies MYSM1 as an ER co-activator that promotes antiestrogen resistance in breast cancer through histone and non-histone deubiquitination.

This study reports the cryo-EM structure of MRGPRX1 bound to an agonist, revealing its activation mechanism and guiding the design of specific modulators for itch and pain treatment.

This paper combines chemical catalysis and microbial consortia to valorize polyethylene deconstruction products into valuable wax esters.

This study shows that TET2 mutations cause DNA damage, activating the cGAS-STING pathway, which drives clonal hematopoiesis and leukemia, and that STING inhibition can suppress these effects in mouse and patient models.

This study shows that inhibiting POLQ in CHO cells enhances CRISPR/Cas9-mediated precise genome editing by increasing knock-in efficiency and reducing random integration.

The paper identifies a host metabolic pathway essential for coronavirus replication and shows that inhibiting it with Propranolol has broad antiviral effects.

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

This study identifies 18 laccase genes in Hypsizygus marmoreus, analyzes their genomic distribution, evolution, and expression patterns, and links specific genes to lignin degradation and fruiting body formation.

The paper shows that sterile tissue injury causes B cell death in Peyers patches via neutrophil-released toxic DNA, leading to tissue shrinkage and reduced secretory IgA.

This study shows that oral nanoplastic exposure in mice leads to gut macrophage activation and IL-1β production, which affects brain function by causing microglial activation and cognitive decline.

This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

This study identifies a SRC-relayed COX2-inflammatory program that drives resistance to BRAF/MEK/EGFR therapies in BRAFV600E colorectal tumors and shows that co-targeting COX2 improves therapeutic outcomes.

This study shows FGFR1 promotes prostate cancer by enhancing iron metabolism through regulation of IRP2 post-translational modification and TFR1 expression.

The paper identifies Zn2+ as a therapeutic agent for calcium oxalate kidney stones by enhancing oxalate-degrading bacteria and their enzymes in the gut microbiota.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

This paper introduces a geometric method to quantify neuromodulatory and inhibitory effects on motor unit discharge patterns using metrics like brace height and slopes, validated on simulated and human data.