C. Wang

This study shows that spontaneous pain induces synchronized neural dynamics in the primary somatosensory cortex, and reversing this synchronization alleviates pain.

This study shows ATM is essential for maintaining meiotic genome stability in Arabidopsis at high temperatures, acting through the MRN complex and chromosome axis, independent of RAD51.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

This study investigates how black soybean peptides alleviate oxidative damage caused by alpha gliadin peptide in a celiac disease cell model.

This study identifies IL-22 as a key immune-to-brain signal that reduces stress-induced anxiety by acting on septal neurons.

The paper identifies host range determinants of ACE2-using MERS-related coronaviruses by analyzing receptor recognition across mammals.

This study identifies acetylation of the fungal effector FolSvp1 as critical for its stability and virulence in tomato plants.

This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.

The paper reports cryo-EM structures of gRAMP-crRNA and gRAMP-crRNA-TPR-CHAT complexes, revealing how TPR-CHAT discriminates between self and non-self RNA targets through conformational changes.

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

This paper identifies LPD-3 as a conserved megaprotein critical for lipid trafficking between ER and PM, essential for cold resilience in C. elegans and other species.

The paper shows polysaccharides trigger deep-sea Lentisphaerae to release chronic bacteriophages that reprogram host polysaccharide metabolism through auxiliary metabolic genes.

This study uses microwave fixation to preserve brain metabolites in mice, showing reduced glucose metabolism in diabetic models and altered metabolic enzyme expression.

This study uses scRNA-seq to analyze EBV latency in lymphoblastoid cells, identifying two distinct clusters with different EBV gene expression and revealing the role of super-enhancers in maintaining latency.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

This study identifies inter-holoenzyme phosphorylation as the mechanism for spreading CaMKII activity, challenging the subunit exchange hypothesis.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This study identifies mce3R mutations causing contezolid resistance in Mycobacterium tuberculosis by increasing Rv1936-mediated drug degradation.

This study identifies active components of Hohgardi-9 and their mechanisms in treating acute lung injury by targeting inflammatory pathways and reducing apoptosis.

This study identifies differential proteins and pathways affected by BF-TK/GCV treatment in gastric cancer cells, showing its anti-metastatic effects through proteomics and functional assays.

The paper creates a temporal single-cell atlas of non-neuronal retinal cells in mice after CNS injury, revealing dynamic multicellular responses and an interferon program.

The paper identifies SNULs, noncoding RNAs that form nucleolar territories on NOR chromosomes and regulate rRNA expression by influencing pre-rRNA sorting and processing.

This study uses single-cell RNA-seq to identify intercellular communication drivers of myocardial fibrosis in diabetic mice, highlighting key ligand-receptor interactions and fibroblast subpopulations involved in fibrosis.

This study identifies a water-soluble fraction of royal jelly that reduces squalene epoxidase expression in liver cells, thereby lowering cholesterol levels.

The paper introduces a microbial risk score (MRS) framework to aggregate microbiome data into a predictive score for disease risk, validated across multiple cohorts.

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

This study identifies PgfA as a periplasmic protein essential for asymmetric polar growth in mycobacteria by coordinating lipid trafficking and cell wall synthesis.

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.