C. Wang

The paper shows that XBAT35.2 modulates FLS2 stability by ubiquitinating ESCRT-I subunits VPS37-1 and VPS28-2 with distinct ubiquitin chains, enhancing plant immunity.

This study compares molecular mechanisms and antiviral targets of Old and New World hantaviruses using human cell models and identifies potential therapeutic compounds.

This study identifies PLK1 as a driver of an immunosuppressive tumor microenvironment in LUAD through single-cell RNA-seq and genetic models.

This study identifies TgCrk4 as a key regulator of the G2 phase in Toxoplasma gondii, controlling chromosome and centrosome cycles, and shows its evolutionary conservation in binary-dividing apicomplexans.

This study shows that PLK1 phosphorylates AHR in LUAD, promoting metastasis through DIO2-TH signaling.

This study identifies humoral immune responses as correlates of protection against Mtb following IV BCG vaccination in rhesus macaques.

The paper shows O-GlcNAcylation of Keratin 18 coordinates TCA cycle enzymes to promote cholangiocarcinoma progression by stabilizing K18 and altering metabolite levels.

The paper improves inter-link detection in cross-linking mass spectrometry by using a fused database and context-sensitive subgrouping, increasing coverage by 30-75% while maintaining low error rates.

This study cultures a novel deep-sea Planctomycetes strain, characterizes its physiology and metabolism, and reveals nitrogen metabolism reprogramming by chronic bacteriophages.

This study identifies hypermutated IGHV3-53/3-66 antibodies from breakthrough infections that broadly neutralize SARS-CoV-2 variants including BQ and XBB.

This study shows that combining proguanil and chlorhexidine with clarithromycin or rifampicin enhances antibacterial activity against Acinetobacter baumannii in vitro and improves treatment outcomes in mice.

This paper describes an injectable spinal stimulator that enables precise and programmable hindlimb movement in mice by targeting ventral spinal regions.

This study presents cryo-EM structures of four E. coli ABCF paralogs bound to the ribosome, revealing their role in modulating tRNA geometry and catalytic function at the peptidyl-transferase center.

This study shows metformin reduces hepatic ischemia/reperfusion injury by altering gut microbiota to increase GABA, which inhibits ferroptosis.

This study identifies the essential role of the COG complex in Toxoplasma gondii, showing its expanded function in membrane trafficking and unique adaptations in the parasite's secretory system.

SeMOE enables absolute glycan quantification and visualization through selenosugar-based metabolic oligosaccharide engineering, with demonstrated anti-cancer potential.

This study shows that the D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice by disrupting nuclear-cytosolic Ca2+ coupling.

OpenABC simplifies GPU-accelerated simulations of biomolecular condensates using Python, offering performance comparable to hundreds of CPUs and tools for converting to all-atom structures.

This study shows that inhibiting subchondral osteoclastogenesis maintains hypoxia in subchondral bone, slowing osteoarthritis progression by stabilizing HIF-1 and reducing cartilage degeneration.

This study shows that disrupting nucleolar structure in HeLa cells affects global nuclear organization, including changes in genomic loci and nuclear bodies, independent of ribosome synthesis inhibition.

This paper uses machine learning to identify latent transcriptional programs in squamous cell carcinomas from histology images, linking them to clinically relevant biological processes.

This study shows Lactococcus G423 improves broiler growth and survival by altering gut microbiota and metabolites, while antibiotics negatively affect microbiota.

This study reveals the structural differences between the oxidized O state and the metastable OH state of cytochrome c oxidase using spectroscopy and crystallography, showing how Y244's protonation state affects proton translocation.

The paper introduces a high-resolution Salmonella subtyping method using MLSTnext-NGS, which efficiently identifies serovars and resolves mixed strains in food samples.

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

This study identifies PRL1's role in maintaining actin microfilament integrity and cellular homeostasis, linking actin depolymerization to root developmental defects in Arabidopsis.

This study identifies PRL1 as a regulator of actin microfilament dynamics in Arabidopsis pavement cells through both Rho GTPase-dependent and -independent pathways.

This study identifies SlCLE10 and SlCLE11 as CLE peptides that suppress arbuscular mycorrhizal colonisation in tomato roots, with SlCLE11 acting locally and SlCLE10 showing a minor or redundant role.

This study induces chronic deep venous thrombosis in canine and porcine models and compares their suitability for translational therapeutic research.