C. Zhang

This study uses single cell RNA sequencing to identify distinct subpopulations of notochord-derived nucleus pulposus cells in postnatal mice, revealing developmental stages and molecular signatures associated with extracellular matrix production.

This study optimizes MP isolation protocols, identifies 3000g as critical for composition, and reveals functional differences between traditional and new MPs.

The paper identifies vacuolar H+-ATPase subunit a as the target of fluopicolide, an oomycete inhibitor, and suggests H+-ATPase as a novel fungicide target.

The paper isolates a Desulforhopalus-dominated community capable of debromination of 2,6-dibromophenol and identifies RDase genes in multiple bins, revealing their ecological roles and potential for bioremediation.

This study identifies novel organohalide-respiring bacteria from Aarhus Bay sediments using genome-resolved transcriptomics, revealing new reductive dehalogenase genes and regulatory mechanisms.

The paper shows that ANP treatment rescues preeclampsia symptoms in Axl knockout mice by improving trophoblast function through the AXL-CORIN-ANP pathway.

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

This study identifies FGF-21's role in promoting renal gluconeogenesis through a liver-brain-kidney axis, linking it to accelerated renal cell carcinoma progression and suggesting Adrb2 blockade as a potential therapy.

The paper constructs a comprehensive gene and genome catalog from cold seep sediments, revealing novel microbial species and a large fraction of uncharacterized genes.

The paper identifies a novel MCR-1 variant with low β-lactam co-resistance and shows synthetic peptides from this variant have broad-spectrum antimicrobial activity.

This study shows asparagine starvation reduces histone demethylation by depleting labile iron, which is essential for JHDMs function, and this effect is mediated through IREB2 and TFRC regulation.

This paper introduces a fast-responding galvo scanning mirror for RT-3D-SPT, improving tracking performance for single molecules and nanoparticles.

This study finds that constitutive expression of the Type VI Secretion System in Vibrio cholerae has a negligible fitness cost, with minimal impact on growth.

The paper shows that a cancer mutation in METTL14 changes RNA methylation specificity, promoting oncogenesis by altering gene expression without increasing global m6A levels.

This paper presents an open-source photogrammetry workflow for 3D model reconstruction and evaluates its geometric accuracy compared to microCT scans.

The paper examines viral genetic features and evolutionary patterns in deep-sea cold seep sediments, identifying diverse survival strategies and genetic conservation within species.

This study shows that endothelial cell lactate promotes BMSC histone lactylation, enhancing osteogenesis and reducing osteoporosis, with exercise increasing lactate to alleviate the condition.

This paper identifies microbiome features distinguishing three patient clusters with abnormal glycometabolism, stratified using unsupervised clustering of clinical parameters.

This study identifies NuSAP's role in regulating metaphase spindle length by controlling microtubule flux and Kif2A localization during mitosis.

The paper designs and evaluates synthetic isopentyldiol pathways in E. coli, finding that a computationally designed pathway produces IPDO at 2.2 mg/L from glucose.

This study shows that lower shear stress promotes neutrophil extracellular traps (NETs) formation, which worsens atherosclerosis by damaging endothelial cells through Piezo1-mediated mechanosensation.

The paper identifies a new AOA order, Nitrosomirales, widespread in marine and terrestrial environments, showing metabolic versatility and horizontal gene transfer.

This paper introduces a zero-shot self-supervised physics-guided deep learning method for real-time cine cardiac MRI, showing improved performance over existing techniques in noise and aliasing reduction.

The paper defines novel osteolineage gene sets using single-cell transcriptomics and identifies molecular defects in a CKD mouse model.

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

The paper investigates intraspecific phenotypic variation in a tropical seedling community, finding alternative phenotypes and their environmental interactions influence growth and species co-occurrence.

This study shows that immune sensing of food allergens drives antigen-specific behavioural aversion in mice, involving IgE, mast cells, and leukotrienes, and extends to lipopolysaccharide-induced inflammation.

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

This study shows that reduced Prolyl oligopeptidase (POP) and its product Ac-SDKP contribute to ovarian fibrosis in PCOS mice by altering MMP-2 and TGF-β1 expression.