D. Chen

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

The paper introduces a new aerosol collection system with high physical and biochemical capture efficiency for viruses and microorganisms, enabling better disease transmission studies and public health monitoring.

The paper identifies meninges as a site for B cell development and CNS-antigen-specific negative selection in mice and NHPs.

This study investigates the conformation and dynamics of the denatured state ensemble (DSE) of a membrane protein in a native lipid bilayer, finding it is dynamic and partially expanded.

This paper introduces an MRI-based data fusion method for simulating aortic haemodynamics, achieving accurate and efficient patient-specific compliant simulations without CT data.

This paper develops a fluorescence-activated droplet sorting pipeline to screen for PET-degrading microorganisms and enzymes, identifying new PETase candidates from environmental samples.

This study uses extracellular flux analysis to detect anti-tuberculosis drug cytotoxicity in different cell types, revealing effects not captured by conventional viability assays.

The paper identifies HemK2/KMT9 as a new target of NTMT1 bisubstrate inhibitor NAH-C3-GPKK through chemoproteomic profiling.

This study characterizes the biophysical properties of tau seeds, showing they are monomeric and can nucleate tau aggregation in vitro and in cells.

This study investigates stochastic motion of biomolecules in SMLM and shows that restricting this motion improves localization precision.

This study identifies recurrent chromosome fusions and gene losses in parrots, revealing the role of transposable elements and genetic drift in neo-sex chromosome evolution.

The paper explores comparative population genetics in the human gut microbiome to identify evolutionary trends and functional categories under different selection pressures.

This paper identifies platelet RNAs that predict occult tumor progression in a mouse melanoma model, showing high diagnostic accuracy for early cancer detection.

The paper generates a single-cell atlas of pig lung using scRNA-seq and develops an online platform to explore lung single-cell data across species.

This study compares the transcriptome responses of SARS-CoV and SARS-CoV-2 in human cell lines, finding broader but weaker host responses for SARS-CoV-2.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

The paper identifies four linear B-cell epitopes on the SARS-CoV-2 spike protein that can elicit neutralizing antibodies in multiple species.

The paper shows lipid exposure alters gene expression and chromatin features in mammary cells, linking these changes to ER-negative breast cancer development.

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

This study identifies NEK2-EZH2 signaling as critical for glioblastoma tumor core progression and resistance, and presents a novel inhibitor CMP3a that shows therapeutic potential.

This study assesses bacterial abundance and diversity in 70-year-old desiccated soils, showing significant resuscitation potential and activity of certain taxa after rewetting.

The paper identifies cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 epitope and its variants, showing their ability to activate and kill infected cells.

This study shows allantoin induces pruritus in CKD by activating MrgprD and TRPV1 in DRG neurons.

The paper investigates fungal and yeast communities in spontaneous wine fermentations, finding geographic differentiation and S. cerevisiae's role in shaping wine aroma profiles.

The paper designs and synthesizes a potent dual-selective bisubstrate inhibitor for PRMT4/5, demonstrating high potency and selectivity with IC50 values of 2.8 nM and <1.5 nM.

This study identifies CD36-mediated lipid peroxidation driven by oxidized lipids as a mechanism suppressing anti-tumor CD8 T cell functions in murine tumors.

This study shows that CHMP5 regulates bone formation by controlling endolysosome-mitochondrion-mediated cell senescence, and targeting senescent cells can alleviate musculoskeletal abnormalities.