D. Chen

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

This study identifies OsHAK18 as a phloem-localized K+ transporter that mediates K+ loading and redistribution in rice, enhancing shoot K+ retention under low-K+ stress.

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

This study isolates a CPR bacterium using epicPCR and reveals its type IV pili-dependent epibiotic lifestyle and twitching motility.

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

This study identifies OsCAX2 as a key gene for cadmium tolerance and accumulation in rice by promoting vacuolar sequestration, reducing grain cadmium levels by over 70%.

This study shows that Gaq-PKD/PKCμ regulates IκB transcription to limit NF-κB-mediated inflammation, essential for successful early pregnancy.

The paper examines how tinamou egg coloration relates to mating signals and eco-geographical distribution, finding associations with song variables and differences in similar habitats.

The paper identifies HLY72, a small-molecule derivative of lycorine, as an anti-obesity agent that targets Na+/K+-ATPase α3 in the brain, promoting lipolysis and thermogenesis without affecting food intake.

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

This study investigates how the FTD-tau S320F mutation stabilizes local structure and promotes amyloid motif-dependent aggregation through allosteric effects.

This study develops an Omicron-specific mRNA vaccine that shows superior neutralizing antibody responses in mice, hamsters, and macaques compared to existing vaccines.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study investigates microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian using RNA-seq and small RNA-seq data, identifying miRNA-target mRNA interactions and their roles in glycolysis, virulence, and immune response.

This study identifies circRNAs in Asian honey bee midguts infected with Nosema ceranae and shows their role in regulating immune responses through miRNA targeting and pathway involvement.

The paper investigates how peptaibol structural diversity in Trichoderma fungi mediates interactions with mycohosts, showing that these compounds are essential for inhibiting saprotrophic fungi.

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

This study introduces spt-PRIS, a new single particle tracking method that improves localization in high-density datasets with overlapping PSFs, showing effectiveness for KRAS4b subpopulation analysis.

This study demonstrates that Notch ligand dimers mediate cis-inhibition of Notch receptor activity, introducing a new model of Notch signaling that distinguishes between ligand monomer-driven transactivation and dimer-mediated cis-inhibition.

This study identifies ILK5 as a downstream substrate of P2K1 kinase that mediates MAPK cascade activation in Arabidopsis, enhancing innate immunity through phosphorylation of MPK3/6.

This paper identifies and calibrates ultrabright localizations in SMLM to improve quantification accuracy for biomolecular organization.

This study identifies versican as a collagen-binding protein that regulates collagen matrix organization and mechanics through its G3 domain.

This study identifies 4-vinylanisole as an aggregation pheromone that promotes sexual maturation synchrony in gregarious female locusts through a juvenile hormone/vitellogenin pathway.

The paper shows that community diversity in the human gut microbiome is linked to intra-species genetic diversity and gene loss, supporting both Diversity Begets Diversity and Black Queen Hypothesis mechanisms.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study shows peramivir reduces cytokine storm by inhibiting NF-κB activity in macrophages and alleviates lung injury in mice.

This study identifies Kindlin-2 as a protective factor in articular cartilage, showing its role in preventing osteoarthritis through regulation of Stat3 and Runx2 pathways.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.