D. Wu

This study identifies Cul5 as a negative feedback regulator of CD8+ T cell signaling and anti-tumor activity, showing its knockout enhances tumor control through proteomic and signaling changes.

The paper was withdrawn due to duplicate posting and is no longer available for citation.

This paper proposes a deep learning model for multi-label bacterial classification, showing it is lighter, faster, more accurate, and efficient than existing methods.

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

The Sticky Pi trap uses AI to monitor insect activity patterns, revealing daily rhythms and community temporal niches without targeting specific species.

This study shows metformin reduces arthrofibrosis in rats by altering fibroblast metabolism, shifting it from oxidative phosphorylation to aerobic glycolysis.

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

This study constructs a spatiotemporal MRI atlas of fetal brain development in Chinese fetuses, revealing a central-to-peripheral cortical growth gradient and dynamic structural asymmetry.

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

The paper analyzes sequence and structural variability in the SARS-CoV-2 nucleocapsid protein, finding high mutability and structural plasticity linked to enhanced viral assembly efficiency.

This paper describes four techniques to improve aptamer discovery, enabling efficient isolation of high-affinity and specific aptamers for challenging targets.

This study demonstrates systemic gene editing using PNA nanoparticles to correct the F508del CFTR mutation in mice, showing partial CFTR function restoration and tissue-specific correction without off-target effects.

This study identifies novel viral genomic components and evolutionary patterns using conserved untranslated regions (UTRs) and UTR-backed iterative BLASTn in multipartite viruses.

This study shows that horizontal gene transfer created momilactone biosynthetic gene clusters in grasses, with subsequent gene recruitment and loss shaping their evolution.

This study uses snRNA-seq and Stereo-seq to analyze the immunological microenvironment of cervical squamous cell carcinoma, identifying immune cell clusters and their associations with tumor progression and patient survival.

This study identifies horizontal transfer of a biosynthetic gene cluster for benzoxazinoids among grasses, revealing evolutionary mechanisms and selection pressures.

The paper introduces an improved model for ion-channel currents that allows for multiple states and incorporates conductance and open probability, demonstrating its applicability with BK and MthK potassium channel data.

The paper uses cryoEM to study endogenous V-ATPase interactions with mEAK-7 in porcine kidney, revealing structural insights and functional differences compared to yeast.

This study identifies a metabolic divergence between human and mouse lung adenocarcinomas due to LKB1-dependent regulation of TPI1 phosphorylation, highlighting limitations of mouse models for studying human cancer.

The paper shows anionic lipids gate potassium conduction through Kir channels by interacting with the internal gate via fatty acyl tails.

The paper determines the structural basis for recognition of two SARS-CoV-2 spike epitopes by T cell receptors, revealing insights into epitope specificity and variation.

This study demonstrates that iDPC-STEM provides superior contrast and structural detail in biological samples compared to conventional TEM, especially at low doses and for thick sections.

This study induces human adipose-derived mesenchymal stem cells into hepatocyte-like cells using small-molecule cocktails and growth factors, producing cells with mature phenotype and function.

This study shows that a single mucosal dose of the live attenuated RSV-based vaccine MV-014-212 protects non-human primates from SARS-CoV-2 infection by reducing viral shedding and inducing neutralizing antibodies.

The paper develops ENVIM, an Elastic Net Model-based method for predicting metabolites from microbiome data, showing improved accuracy over existing methods in oral, gut, and vaginal microbiome datasets.

This paper introduces an ultrafast nonlinear ultrasound imaging technique that improves sensitivity, field of view, and frame rate for molecular and hemodynamic imaging.

This paper introduces a generalized kinetic model to describe ion-permeation mechanisms in ion channels using patch-clamp data.

This study examines how different control interfaces affect the validity and reliability of using heart-rate variability features to monitor mental workload during powered wheelchair operation.